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2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide

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2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:iCRT-3
CAS:901751-47-1
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: InvivoChem
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Products Intro: Product Name:iCRT3
CAS:901751-47-1
Purity:98% Package:5mg Remarks:V3194
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:iCRT3
CAS:901751-47-1
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
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Products Intro: Product Name:iCRT-3
CAS:901751-47-1
Purity:98%+ Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Henan Fengda Chemical Co., Ltd
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Products Intro: Product Name:iCRT3
CAS:901751-47-1
Purity:99% Package:1KG;25kg;200kg;1000kg Jessica Remarks:g-kg-tons,free sample is available.Bottle/drum/IBC.Advantage products,new batches,regular stock, ready for shipment.
2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Basic information
Product Name:2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide
Synonyms:2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide;CS-2716;ICRT3;ICRT-3;ICRT 3;Acetamide, 2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)-;iCRT3;Inhibitor,Wnt,Apoptosis,inhibit,iCRT-3,iCRT3,iCRT 3
CAS:901751-47-1
MF:C23H26N2O2S
MW:394.53
EINECS:
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Mol File:901751-47-1.mol
2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Structure
2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Chemical Properties
density 1.150±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥5mg/mL
form powder
pka14.62±0.46(Predicted)
color white to tan
Safety Information
Hazard Codes Xn
Risk Statements 22-37/38-41
Safety Statements 26-39
WGK Germany 3
MSDS Information
2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Usage And Synthesis
UsesiCRT3, is an inhibitor of both Wnt and β-catenin-responsive transcription (CRT).
UsesiCRT3 has been used:
  • for β- catenin inhibition in dual luciferase assay
  • to inhibit β-catenin /TCF interactions and their transcriptional activity
  • as wingless/tailess (wnt) antagonist, to determine Wnt/β-catenin signaling is essential for PROX1-mediated regulation of forkhead box protein C2 (FOXC2)(3)catenin inhibition in dual luciferase assay
  • to inhibit β- catenin /TCF interactions and their transcriptional activity
  • as wingless/tailess (wnt) antagonist, to determine Wnt/β-catenin signaling is essential for PROX1-mediated regulation of forkhead box protein C2 (FOXC2)

General DescriptioniCRT3 is a small cell-permeable oxazole compound. It blocks cytokine secretion in lipopolysaccharide (LPS)-stimulated macrophages.
Biochem/physiol ActionsThe key mediator of Wnt signaling is the transcriptional co-activator b-catenin. In the cytoplasm, b-catenin is tightly bound to a complex that includes Axin and GSK-3b. Stimulation causes b-catenin stabilization, translocation to the nucleus and association with TCF4 to initiate transcription of responsive genes, referred to as Catenin Responsive Transcription (CRT). Virtually all Wnt-associated cancers are the result of misregulated CRT. Three inhibitors of CRT (iCRT) were identified in a screen that employed RNAi based knockdown of Axin, which stimulates CRT without affecting upstream mechanisms such as GSK activity, transduction by disheveled / frizzled, etc. These compounds are potent inhibitors of CRT reporter genes, as well as endogenous gene targets. The compounds also disrupt b-catenin-TCF4 interaction in a dose dependent manner, and cause G0/G1 arrest in colon tumor lines.
2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Preparation Products And Raw materials
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