- Daprodustat
-
- $0.00 / 1g
-
2021-10-08
- CAS:960539-70-2
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 100kgs
- daprodustat,GSK1278863
-
- $1.00 / 1ASSAYS
-
2019-09-06
- CAS:960539-70-2
- Min. Order: 1ASSAYS
- Purity: 95%~99%
- Supply Ability: per week:100kg
Related articles - Synthesis of Daprodustat
- Daprodustat is synthesised using malonic acid as a raw material by Biginelli reaction, saponification and other reactions.
- Dec 21，2023
|
| | daprodustat,GSK1278863 Basic information |
| Product Name: | daprodustat,GSK1278863 | | Synonyms: | daprodustat,GSK1278863;GSK1278863;Daprodustat;2-(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carboxamido)acetic acid;N-[(1,3-Dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]glycine;GSK1278863; GSK 1278863; GSK-1278863; DAPRODUSTAT;2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid;GSK1278863,daprodustat | | CAS: | 960539-70-2 | | MF: | C19H27N3O6 | | MW: | 393.43 | | EINECS: | 691-659-9 | | Product Categories: | API | | Mol File: | 960539-70-2.mol |  |
| | daprodustat,GSK1278863 Chemical Properties |
| Melting point | 237-241oC | | density | 1.359±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), DMSO (Slightly) | | pka | 3.44±0.10(Predicted) | | form | Solid | | color | White to Off-White |
| | daprodustat,GSK1278863 Usage And Synthesis |
| Uses | Daprodustat is a novel HIF (Hypoxia inducible factor)-prolyl hydroxylase inhibitor. | | Biological Activity | daprodustat (gsk1278863) is a hif-prolyl hydroxylase inhibitor.hypoxia stimulates erythropoietin (epo) release through accumulation of hypoxia-inducible factor 1α (hif-1α), resulting in an increase of erythrocyte production by the bone marrow. hif-prolyl hydroxylase inhibitors have been used to selectively activate the phd-signaling pathway, leading to the stabilization of hifα subunits, which can affect the transcription of hif-responsive genes. | | in vitro | in-vitro biotransformation data indicated that gsk1278863 was primarily metabolized by cyp2c8 [1]. | | references | [1] hara k,takahashi n,wakamatsu a,caltabiano s. pharmacokinetics, pharmacodynamics and safety of single, oral doses of gsk1278863, a novel hif-prolyl hydroxylase inhibitor, in healthy japanese and caucasian subjects. drug metab pharmacokinet.2015 dec;30(6):410-8.
[2] brigandi ra,johnson b,oei c,et al. a novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (gsk1278863) for anemia in ckd: a 28-day, phase 2a randomized trial. am j kidney dis.2016 jun;67(6):861-71. |
| | daprodustat,GSK1278863 Preparation Products And Raw materials |
|