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CYTOCHALASIN B

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CAS:14930-96-2
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CAS:14930-96-2
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Products Intro: Product Name:Cytochalasin B
CAS:14930-96-2
Purity:99% Package:1KG;1USD

CYTOCHALASIN B manufacturers

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  • $1.00 / 1KG
  • 2020-05-10
  • CAS: 14930-96-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20T
  • CYTOCHALASIN B
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  • $1.00 / 1ASSAYS
  • 2019-07-10
  • CAS:14930-96-2
  • Min. Order: 1ASSAYS
  • Purity: 98%
  • Supply Ability: 1kg,2kg,100kg
CYTOCHALASIN B Basic information
Product Name:CYTOCHALASIN B
Synonyms:CytochalasinB from Drechslera dematioidea,Phomin;Cytochalasin B, froM Drechslera deMatoidea;Cytochalasin B (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione;Cytochalasin B from Helminthosporium dematioideum ;ec[2,3-d]isoindole-2,18(5h)-dione;(E,E)-16-BENZYL-6,7,8,9,10,12A,13,14,15,15A,16,17-DODECAHYDRO-5,13-DIHYDROXY-9,15-DIMETHYL-14-METHYLENE-2H-OXACYCLOTETRADE[2,3-D]ISOINDOLE-2,18(5H)-DIONE;CYTOCHALASIN B, HELMINTHOSPORIUM DEMATIOIDEUM;CYTOCHALASIN B
CAS:14930-96-2
MF:C29H37NO5
MW:479.61
EINECS:239-000-2
Product Categories:antibiotic
Mol File:14930-96-2.mol
CYTOCHALASIN B Structure
CYTOCHALASIN B Chemical Properties
Melting point 218-223 °C
Boiling point 577.96°C (rough estimate)
density 1.1490 (rough estimate)
refractive index 1.6290 (estimate)
Fp 85℃
storage temp. -20°C
solubility ethanol: 20 mg/mL
form powder
pka13.60±0.70(Predicted)
color white
Merck 13,2819
BRN 1096207
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKeyUXVDBQLLXVKPRS-UZBFCAAUSA-N
LogP3.370
EPA Substance Registry SystemCytochalasin B (14930-96-2)
Safety Information
Hazard Codes T+,T
Risk Statements 26/27/28-63-23/24/25
Safety Statements 28-36/37-45
RIDADR UN 1544 6.1/PG 2
WGK Germany 3
RTECS RO0205000
10
HazardClass 6.1(a)
PackingGroup I
HS Code 29349990
Hazardous Substances Data14930-96-2(Hazardous Substances Data)
ToxicityLD50 intraperitoneal in mouse: 30mg/kg
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
CYTOCHALASIN B Usage And Synthesis
DescriptionCytochalasin B (14930-96-2) is a cell permeable fungal toxin which binds to the barbed end of actin, inhibiting its polymerization.1 Inhibits cell division, migration and glucose transport.2 Causes cell cycle arrest at G2/M and induces apoptosis in HCT-116 colorectal carcinoma cells.3? Cytochalasin B-induced membrane vesicles (CIMVs) retain cell surface receptors of the parent cells and retain fusion specificity with target cells.4 CIMVs are a promising new vector system for drug and biomolecule delivery due to their natural origin and participation in intercellular communication.5
Chemical Propertieswhite to off-white powder
UsesA cell-permeable fungal toxin used in actin polymerization studies and cytological
UsesCytochalasin B is one of the most extensively studied members of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalsins, cytochalasin B exhibits potent inhibition of actin filament function leading to cell death by apoptosis, and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of this class display diverse selectivity. However, lack of comparative co-metabolite analysis has restricted a more complete understanding of their individual selectivity.
UsesAs tools in cytological research and in characterization of polymerization properties of actin, q.v.
DefinitionChEBI: An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.
General DescriptionCytochalasin B is a cell-permeable fungal toxin / mycotoxin that binds to the ′barbed′ end of actin / actin filaments. This binding leads to:
  • Disruption of actin filaments and of interaction of actin filaments in solution
  • Inhibition of actin polymerization
  • Inhibition of subunit association and dissociation
Cytochalasin B is widely used in studies of glucose transporters (GLUT). Cytochalasin B is also used as an integral part of various in vitro micronucleus assay protocols.
Biochem/physiol ActionsCell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
storageStore at -20°C
Purification MethodsPurify it by MeOH extraction, reverse phase C18 silica gel batch extraction by selective elution with 1:1 v/v hexane/tetrahydrofuran, crystallisation, subjected to TLC and recrystallisation [Lipski et al. Anal Biochem 161 332 1987]. It is soluble in EtOH (3.6%), Me2CO (1%), Me2SO (37%) and Me2NCHO (49%) at 24o, and can be crystallised from the first two solvents. It interferes with cellular movement [Korm Physiol Reviews 62 672 1982].
ReferencesThreadoropoulos et al. (1994), Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping; Biochem. Pharmacol., 47 1875 Whitesell et al. (2005), Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line; Biochem. J., 386 245 Buldak et al. (2014), Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment; Eur. J. Histochem., 58 2408 Gomzikova et al. (2018), Evaluation of cytochalasin B-Induced Membrane Vesicles Fusion specificity with Target Cells; Biomed. Res. Int., 2018 7053623 Gomzikova et al. (2017), Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells; Oncotarget, 8 70496
CYTOCHALASIN B Preparation Products And Raw materials
Preparation ProductsCYTOCHALASIN A
Tag:CYTOCHALASIN B(14930-96-2) Related Product Information
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