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T-2 TOXIN

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Company Name: Hebei Yanxi Chemical Co., Ltd.
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CAS:21259-20-1
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CAS:21259-20-1
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CAS:21259-20-1
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T-2 TOXIN manufacturers

  • T-2 TOXIN
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  • $50.00 / 1kg
  • 2023-09-08
  • CAS:21259-20-1
  • Min. Order: 1kg
  • Purity: 0.99
  • Supply Ability: 10000
  • T-2 TOXIN
  • T-2 TOXIN pictures
  • $3.00 / 1KG
  • 2020-01-19
  • CAS:21259-20-1
  • Min. Order: 1KG
  • Purity: 98%
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T-2 TOXIN Basic information
Product Name:T-2 TOXIN
Synonyms:4β,15-Diacetoxy-8α-(3-Methylbutyryloxy)- 12,13-epoxytrichothec-9-en-3α-ol;8α-(3-Methylbutyryloxy)-4β,15- diacetoxyscirp-9-en-3α-ol;T-2 LienoMycin;T-2 Toxin, froM FusariuM tricinctuM;12,13-epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol4,15-diacetate8;12,13-trichothecene;3alpha-Hydroxy-4beta,15-diacetoxy-8alpha(3-methylbutyryloxy)-12,13-epoxy-trichothec-9-ene;3alpha-hydroxy-4beta-15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-delt
CAS:21259-20-1
MF:C24H34O9
MW:466.53
EINECS:244-297-7
Product Categories:
Mol File:21259-20-1.mol
T-2 TOXIN Structure
T-2 TOXIN Chemical Properties
Melting point 151.5℃
alpha D26 +15° (c = 2.58 in ethanol)
Boiling point 489.35°C (rough estimate)
density 1.1942 (rough estimate)
refractive index 1.6230 (estimate)
Fp 2 °C
storage temp. −20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
form powder
pka13.24±0.70(Predicted)
color white
Merck 13,9872
IARC3 (Vol. 31, Sup 7) 1987
Safety Information
Hazard Codes T+,T,Xn,F
Risk Statements 26/27/28-38-36-20/21/22-11
Safety Statements 28-36/37-45-36-26-16-36/37/39-22
RIDADR UN 3462 6.1/PG 1
WGK Germany 3
RTECS YD0100000
10-21
HazardClass 6.1(a)
PackingGroup I
HS Code 29329990
Hazardous Substances Data21259-20-1(Hazardous Substances Data)
ToxicityLD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer)
MSDS Information
ProviderLanguage
SigmaAldrich English
T-2 TOXIN Usage And Synthesis
DescriptionT-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.
Chemical PropertiesWhite powder
UsesT-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.
DefinitionChEBI: T-2 toxin is a trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. It has a role as a mycotoxin, a cardiotoxic agent, a neurotoxin, an environmental contaminant, an apoptosis inducer, a DNA synthesis inhibitor and a fungal metabolite. It is a trichothecene, an acetate ester and an organic heterotetracyclic compound. It is functionally related to a HT-2 toxin.
General DescriptionT-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains.
Safety ProfilePoison by ingestion, intramuscular, subcutaneous, intraperitoneal, intracerebral, and intravenous routes. Moderately toxic by inhalation. Experimental teratogenic and reproductive effects. A skin irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
T-2 TOXIN Preparation Products And Raw materials
Preparation ProductsNEOSOLANIOL
Tag:T-2 TOXIN(21259-20-1) Related Product Information
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