1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑 CAS#: 162054-19-5

1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑

中文名称	1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑
中文同义词	1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑;5-(4-氟苯基)-1-(4-(甲基磺酰基)苯基)-3-(三氟甲基)-1H-吡唑;化合物SC 58125
英文名称	1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE
英文同义词	SC-58125;1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)pyrazole;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3-trifluoromethyl-1H-pyrazole;1H-Pyrazole, 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-;Cyclooxygenase,cancer,SC58125,COX,Inhibitor,SC-58125,inflammatory,antitumor,COX-2,edema,inhibit
CAS号	162054-19-5
分子式	C17H12F4N2O2S
分子量	384.35
EINECS号
相关类别
Mol文件	162054-19-5.mol
结构式

1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑性质

储存条件	Store at +4°C
溶解度	二甲基亚砜：≥20mg/mL
形态	粉末
颜色	白色至类白色

1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑用途与合成方法

生物活性

SC-58125 是一种有效的和选择性的环氧合酶 2 (COX-2) 的抑制剂，IC50 值为 0.04 μM。SC-58125 在体外和体内均表现出抗肿瘤活性，还可以抑制炎症部位的水肿并具有镇痛作用。

靶点

hCOX-2

0.04 μM (IC ₅₀ )

hCOX-1

>100 μM (IC ₅₀ )

体外研究

SC-58125 (0.001-100 μM) has a high degree of selectivity for the inducible form of COX-2 (IC ₅₀ =1 μM) over the COX-1 (IC ₅₀ >100 μM).
SC-58125 (10 μM; 20-140 s) is time-dependent and is complete by 1 min, with a half-maximal inhibition at 20 s.
SC-58125 (25-100 μM; 3 d) inhibits the in vitro growth of HCA-7 and LLC cells.
SC-58125 (100 µM; 12 h) induces G ₂ arrest in LLC cells.
SC-58125 (25-100 μM; 3 d) decreases p34 ^cdc2 levels in HCA-7 cells.
SC-58125 (100 µM; 24 or 72 h) does not induce apoptosis of HCA-7 and LLC cells.

Cell Proliferation Assay

Cell Line:	HCA-7 and LLC cells
Concentration:	0, 25, 50, 100 μM
Incubation Time:	3 days
Result:	Reduced the cell number and MTT activity in both cell lines in a dose-dependent manner.

Cell Cycle Analysis

Cell Line:	LLC cells
Concentration:	100 μM
Incubation Time:	12 hours
Result:	Increased in the number of cells containing 4n DNA content in a dose- and time-dependent manner. Reduced the number of mitotic figures.

Western Blot Analysis

Cell Line:	HCA-7 cells
Concentration:	0, 25, 50, 100 μM
Incubation Time:	3 days
Result:	Resulted in a dose-dependent decrease in p34 ^cdc2 activity with strong inhibition, even at the lowest concentration.

体内研究

SC-58125 (10 mg/kg; i.p. every 48 h) inhibits the growth of established colorectal cancer xenografts in mice.
SC-58125 (10 mg/kg; a single i.p.) reduces tumor PGE2 levels in mice.
SC-58125 (10 mg/kg; a single i.p.) does not change the tumor levels of COX-1 and COX-2 protein in mice.

Animal Model:	Athymic Sprague-Dawley mice are injected HCA-7 cells
Dosage:	10 mg/kg
Administration:	I.p. every 48 h; at the time of tumor implantation or 2 and 4 weeks later
Result:	Decreased the tumor growth rates significantly.

安全信息

危险品标志	T
危险类别码	25
安全说明	45-24/25-22
WGK Germany	3

1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑