氯瑞唑
| 中文名称 | 氯瑞唑 |
|---|---|
| 中文同义词 | 氯瑞唑;(Z)-1-(2-氯-2-(2,4-二氯苯基)乙烯基)-1H-1,2,4-三唑;盐酸洛雷唑 |
| 英文名称 | (Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride |
| 英文同义词 | LoreclezoleHCl;Loreclezole;1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1,2,4-triazole;1-[(Z)-2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole;R-72063;(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole hydrochloride;1H-1,2,4-Triazole, 1-[(1Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-;γ-Aminobutyric acid Receptor,R 72063,Inhibitor,GABA Receptor,Loreclezole,Gamma-aminobutyric acid Receptor,R72063,R-72063,inhibit |
| CAS号 | 117857-45-1 |
| 分子式 | C10H6Cl3N3 |
| 分子量 | 274.53 |
| EINECS号 | |
| 相关类别 | GABA/Glycine receptor |
| Mol文件 | 117857-45-1.mol |
| 结构式 |  |
氯瑞唑 性质
| 储存条件 | Inert atmosphere,2-8°C |
|---|---|
| 溶解度 | <1.37mg/ml，溶于 DMSO； <1.37mg/ml，在乙醇中 |
Loreclezole 是一种抗癫痫化合物，是选择性的 GABAA 受体 的调节剂，是 β2 或 β3 亚单位包含受体的正向变构调节剂。
GABA A receptor.
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test.
| Animal Model: | Adult male Lister Hooded rats. |
| Dosage: | 10, 25, 50 or 75 mg/kg. |
| Administration: | IP, 60 min before measurement of seizure threshold. |
| Result: | Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-105272 | Loreclezole | 1 mg | 545元 | |
| 2024/04/30 | HY-105272 | 氯瑞唑 Loreclezole | 117857-45-1 | 5mg | 1200元 |