| Company Name: |
Changzhou Hopschain Chemical Co.,Ltd.
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| Tel: |
0519-85528066 13775048983 |
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sales@hopschem.com |
| Products Intro: |
Product Name:5-{[(4-chlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-amine
CAS:72836-33-0
Purity:95+% Package:100mg;250mg;500mg;1g;2.5g;5g;10g
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| Company Name: |
Nanjing Shizhou Biology Technology Co.,Ltd
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| Tel: |
025-85563444 15850508050 |
| Email: |
info@synzest.com |
| Products Intro: |
Product Name:2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE
CAS:72836-33-0
Purity:95% Package:1g;5g;10g
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| Company Name: |
Combi-Blocks Inc.
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858 635 8950 |
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sales@combi-blocks.com |
| Products Intro: |
Product Name:2-Amino-5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazole
CAS:72836-33-0
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| Company Name: |
SynQuest Laboratories, Inc.
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| Tel: |
904 462 0788 |
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info@synquestlabs.com |
| Products Intro: |
Product Name:2-Amino-5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazole
CAS:72836-33-0
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| Company Name: |
Apollo Scientific Ltd.
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| Tel: |
44 161 406 0505 |
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sales@apolloscientific.co.uk |
| Products Intro: |
Product Name:2-Amino-5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazole
CAS:72836-33-0
Package:￡280.00/1g Remarks:OR13143
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| | 2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Basic information |
| Product Name: | 2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE | | Synonyms: | TIMTEC-BB SBB005594;5-((4-CHLOROBENZYL)THIO)-1,3,4-THIADIAZOL-2-AMINE;5-[(4-CHLOROBENZYL)SULFANYL]-1,3,4-THIADIAZOL-2-AMINE;5-[(4-CHLOROBENZYL)SULFANYL]-1,3,4-THIADIAZOL-2-YLAMINE;2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE;5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine;5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-amine;[5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazol-2-yl]amine | | CAS: | 72836-33-0 | | MF: | C9H8ClN3S2 | | MW: | 257.76 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Chemical Properties |
| Melting point | 168-169 °C(Solv: ethyl acetate (141-78-6)) | | Boiling point | 443.8±47.0 °C(Predicted) | | density | 1.50±0.1 g/cm3(Predicted) | | pka | 2.41±0.10(Predicted) |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2934999090 |
| | 2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Usage And Synthesis |
| Definition | ChEBI: 5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-amine is an aryl sulfide. | | General Description | An orally bioavailable, non-toxic, thio-thiadiazolamine compound that specifically inhibits the DNA-binding capacity of virulence regulator, RegA (IC50 = 1.7 μM in E. coli strain MC4100 (kfc-lacZ, pACYC184-regA), by interacting with amino acid residues within a conserved region of the DNA-binding domain, but without affecting RegA dimerization. Interacts with the double helix-turn-helix (HTH) domain that results in a loss of binding affinity of RegA for its DNA targets. This interaction appears to involve W188 and R223 residues that are conserved in several RegA homologs including ToxT, AggR, RegR, and Rns. Shown to be highly effective in reducing Citrobacter rodentium colonization when administered perorally to mice (~50 mg/kg) either 15 minutes before or 12 hours after bacterial inoculation. Reduces the ability of Rns and RegR to activate the transcription of their target promoters, but does not affect the activity of AggR and ToxT.
Please note that the molecular weight for this compound is batch-specific due to variable water content. | | Biochem/physiol Actions | Cell permeable: yes |
| | 2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Preparation Products And Raw materials |
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