EZATIOSTAT游离的
| 中文名称 | EZATIOSTAT游离的 |
|---|---|
| 中文同义词 | EZATIOSTAT游离的;GSTP1-1抑制剂(EZATIOSTAT);EZATIOSTAT游离;(S)-2-氨基-5-(((R)-3-(苄基硫基)-1-(((R)-2-乙氧基-2-氧代-1-苯乙基)氨基)-1-氧代丙烷-2-基)氨基)-5-氧代戊酸乙酯 |
| 英文名称 | Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- |
| 英文同义词 | (S)-ETHYL 2-AMINO-5-((R)-3-(BENZYLTHIO)-1-((R)-2-ETHOXY-2-OXO-1-PHENYLETHYLAMINO)-1-OXOPROPAN-2-YLAMINO)-5-OXOPENTANOATE;(2R)-L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine 1,3-diethyl ester;Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-;Ezatiostat;Terrapin 199;Ezatiostat, >=98%;Ezatiostat, >96%;CS-1110 |
| CAS号 | 168682-53-9 |
| 分子式 | C27H35N3O6S |
| 分子量 | 529.65 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;抑制剂;科研试剂 |
| Mol文件 | 168682-53-9.mol |
| 结构式 |  |
EZATIOSTAT游离的 性质
| 熔点 | >94°C (dec.) |
|---|---|
| 沸点 | 749.7±60.0 °C(Predicted) |
| 密度 | 1.216±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 酸度系数(pKa) | 12?+-.0.46(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| Target | Value |
|
GSTP1-1
() | |
|
JNK1
() | |
|
ERK1/ERK2
() |
Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone.
Selection of a resistant clone of an HL60 tumor cell line through chronic exposure to Ezatiostat (TLK199) results in cells with elevated activities of c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2, and allowes the cells to proliferate under stress conditions that induced high levels of apoptosis in the wild type cells.
Administration of Ezatiostat (TLK199), stimulates both lymphocyte production and bone marrow progenitor (colony-forming unit-granulocyte macrophage) proliferation, but only in glutathione S-transferase P1-1 (GSTP1 +/+ ) and not in GSTP1 -/- animals.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-13634A | EZATIOSTAT游离的 Ezatiostat | 168682-53-9 | 5mg | 744元 |
| 2024/04/30 | S9698 | EZATIOSTAT游离的 Ezatiostat | 168682-53-9 | 5mg | 795.31元 |