| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:GW 610
CAS:872726-44-8
Package:100Mg,10Mg
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| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:NSC 721648 PMX 610
CAS:872726-44-8
Purity:98% HPLC Package:100mg;500mg;1g;5g;10g
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- GW 610
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- $38.00 / 5mg
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2024-10-28
- CAS:872726-44-8
- Min. Order:
- Purity: 99.23%
- Supply Ability: 10g
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| Product Name: | GW 610 | | Synonyms: | GW 610;NSC 721648;NSC 721648 - CAS 872726-44-8 - Calbiochem;NSC 721648 PMX 610;GW 610,colon,Inhibitor,GW610,NSC721648,inhibit,breast,antitumor,NSC 721648,lung,GW-610,NSC-721648;Benzothiazole, 2-(3,4-dimethoxyphenyl)-5-fluoro-;2-(3,4-Dimethoxyphenyl)-5-fluorobenzo[d]thiazole | | CAS: | 872726-44-8 | | MF: | C15H12FNO2S | | MW: | 289.3246832 | | EINECS: | | | Product Categories: | Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 872726-44-8.mol |  |
| | GW 610 Chemical Properties |
| Melting point | 110 °C | | Boiling point | 422.8±55.0 °C(Predicted) | | density | 1.293±0.06 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | DMF:10.0(Max Conc. mg/mL);34.56(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:9.5(Max Conc. mg/mL);32.84(Max Conc. mM) | | form | White crystalline solid | | pka | 0.73±0.10(Predicted) | | color | Light yellow to brown |
| | GW 610 Usage And Synthesis |
| Description | GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed. Potent and selective activity was also observed in the NCI 60 human cancer cell line panel. In contrast with previously reported 2-(4-aminophenyl)benzothiazoles, GW 610 is not reliant on induction of cytochrome P 1A1 (CYP1A1) expression for antitumor activity. | | Uses | GW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity. |
| | GW 610 Preparation Products And Raw materials |
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