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| | SEN 12333 Basic information |
| Product Name: | SEN 12333 | | Synonyms: | SEN 12333;4-MorpholinepentanaMide, N-[4-(3-pyridinyl)phenyl]-;N-[4-(3-Pyridinyl)phenyl]-4-MorpholinepentanaMide;WAY 317538;SEN 12333 WAY-317538;5-Morpholino-N-(4-(pyridin-3-yl)phenyl)pentanamide;Neuroprotective,nAChR,Inhibitor,SEN-12333,WAY317538,SEN12333,Alzheimer's Disease,inhibit,WAY 317538,Nicotinic acetylcholine receptors,schizophrenia,WAY-317538 | | CAS: | 874450-44-9 | | MF: | C20H25N3O2 | | MW: | 339.43 | | EINECS: | | | Product Categories: | Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 874450-44-9.mol |  |
| | SEN 12333 Chemical Properties |
| storage temp. | Store at RT | | solubility | Soluble to 100 mM in DMSO | | form | Powder |
| | SEN 12333 Usage And Synthesis |
| Uses | SEN 12333 is a nicotinic acetylcholine receptor (nAChR) agonist. SEN 12333 displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. SEN 12333 is a brain penetrant and orally bioavailable. |
| | SEN 12333 Preparation Products And Raw materials |
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