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| | CALPHOSTIN C Basic information |
| Product Name: | CALPHOSTIN C | | Synonyms: | CALPHOSTIN C;CALPHOSTIN C FROM CLADOSPORIUMCLADOSPORI OIDES;UCN-1028C;(R)-Calphostin C;1-[(R)-2-(4-Hydroxyphenoxycarbonyloxy)propyl]-2,6,7,11-tetramethoxy-4,9-dihydroxy-12-[(R)-2-(benzoyloxy)propyl]-3,10-dihydroperylene-3,10-dione;4,9-Dihydroxy-12-[(R)-2-(4-hydroxyphenyloxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-1-[(R)-2-benzoyloxypropyl]perylene-3,10-dione;Calphostin C,98%;Calphostin CUCN-1028C | | CAS: | 121263-19-2 | | MF: | C44H38O14 | | MW: | 790.76 | | EINECS: | | | Product Categories: | | | Mol File: | 121263-19-2.mol |  |
| | CALPHOSTIN C Chemical Properties |
| Boiling point | 1039.8±65.0 °C(Predicted) | | density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMF: 1 mg/mL | | form | powder | | pka | 7.30±0.20(Predicted) | | color | red to brown |
| | CALPHOSTIN C Usage And Synthesis |
| Chemical Properties | Dark red solid | | Uses | Potent inhibitor of protein kinase C | | Uses | Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines. | | Uses | Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines. | | Biological Activity | Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM). | | Biochem/physiol Actions | Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro. | | storage | +4°C (desiccate) |
| | CALPHOSTIN C Preparation Products And Raw materials |
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