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POLYOXYETHYLATEDCASTOROIL

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POLYOXYETHYLATEDCASTOROIL Basic information
Product Name:POLYOXYETHYLATEDCASTOROIL
Synonyms:POLYOXYETHYLATEDCASTOROIL
CAS:60649-23-2
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
POLYOXYETHYLATEDCASTOROIL Structure
POLYOXYETHYLATEDCASTOROIL Chemical Properties
Safety Information
MSDS Information
POLYOXYETHYLATEDCASTOROIL Usage And Synthesis
Brand nameCremophor rh40;Cremophor rh60.
World Health Organization (WHO)Polyoxyethylated castor oil is a non-ionic emulsifying agent produced by reacting ethylene oxide with castor oil. It has been used for over 20 years to prepare stable injectable liquid preparations of drugs with low aqueous solubility. By the mid-1970s, its use had been associated with cases of severe anaphylactoid reactions and haematological changes including hyperlipidaemia, altered blood viscosity and erythrocyte aggregation. For the formulation of certain lipophilic substances such as ciclosporin there is currently no viable alternative to this pharmaceutical aid. It continues to be approved in some countries whereas its use is restricted or banned in others. One manufacturer has withdrawn worldwide all products containing polyoxyethylated castor oil.
POLYOXYETHYLATEDCASTOROIL Preparation Products And Raw materials
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