| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:TMI 005
CAS:287405-51-0
Purity:99% Remarks:TMI 005, also known as Apratastat, is a matrix metalloproteinase/tumour necrosis factor-α convertase (MMP/TACE) inhibitor for the treatment of rheumatoid arthritis. It inhibits secretion of soluble TN
|
|
| | apratastat Basic information |
| Product Name: | apratastat | | Synonyms: | apratastat;N-hydroxy-4-[[4-[(4-hydroxy-2-butynyl)oxy]phenyl]sulfonyl]-2,2-dimethyl-3-thiomorpholinecarboxamide;TMI 005;TMI 005 - Apratastat;3-Thiomorpholinecarboxamide, N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-, (3S)-;Apratastat >=98% (HPLC) | | CAS: | 287405-51-0 | | MF: | C17H22N2O6S2 | | MW: | 414.5 | | EINECS: | | | Product Categories: | | | Mol File: | 287405-51-0.mol |  |
| | apratastat Chemical Properties |
| density | 1.390 | | storage temp. | Store at -20°C | | solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid | | pka | 9.25±0.23(Predicted) |
| | apratastat Usage And Synthesis |
| Uses | Treatment of rheumatoid
arthritis. | | Definition | ChEBI: Apratastat is a sulfonamide. | | Brand name | (Wyeth). |
| | apratastat Preparation Products And Raw materials |
|