稗草畏
| 中文名称 | 稗草畏 |
|---|---|
| 中文同义词 | O-3-特丁基苯基-6-甲氧基-2-吡啶(甲基)硫代氨基甲酸酯(稗草畏);稗草丹;O-3-特丁基苯基-6-甲氧基-2-(吡啶(甲基)硫代氨基甲酸酯;稗草畏;椑草畏;O-3-特丁基苯基-6-甲氧基-2-吡啶(甲基)硫代氨基甲酸酯;甲苯中稗草丹标准品;稗草丹 标准品 |
| 英文名称 | Pyributicarb |
| 英文同义词 | carbamothioicacid,(6-methoxy-2-pyridinyl)methyl-,o-(3-(1,1-dimethylethyl)p;henyl)ester;n-(6-methoxy-2-pyridyl)-n-methyl-thiocarbamicacio-3-tert-butylphenyleste;tsh-888;PYRIBUTICARB;PYRIBUTYCARB;n-(6-methoxy-2-pyridyl)-n-methylthiocarbamic acid o-3-tert-butylphenyl ester;O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate |
| CAS号 | 88678-67-5 |
| 分子式 | C18H22N2O2S |
| 分子量 | 330.44 |
| EINECS号 | |
| 相关类别 | 分析标准品;除草剂 |
| Mol文件 | 88678-67-5.mol |
| 结构式 |  |
稗草畏 性质
| 熔点 | 85～88℃ |
|---|---|
| 沸点 | 427.8±55.0 °C(Predicted) |
| 密度 | 1.1453 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 储存条件 | 0-6°C |
| 溶解度 | DMSO：100 mg/mL (302.63 mM)；水：< 0.1 mg/mL（不溶） |
| 酸度系数(pKa) | 1.22±0.10(Predicted) |
CYP3A4, hPXR
Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF).
Pyributicarb causes enhancement of CYP3A4 -derived reporter activity in mouse livers introduced with hPXR by adenovirus.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-111202 | 稗草畏 Pyributicarb | 88678-67-5 | 50mg | 990元 |
| 2024/01/25 | HY-111202 | 稗草畏 Pyributicarb | 88678-67-5 | 10mM * 1mLin DMSO | 1089元 |