吡咯烷二硫代甲酸铵盐
中文名称 | 吡咯烷二硫代甲酸铵盐 |
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中文同义词 | 吡咯烷二硫代甲酸铵;四次甲基二硫代氨基甲酸铵;四亚甲基二硫代氨基甲酸铵;1-吡咯烷硫代羧酸铵盐/吡咯二硫代甲酸铵;1-吡咯烷羰基二硫酸铵盐;吡咯烷二硫代甲酸铵盐;1-吡咯烷硫代氨基甲酸铵盐;1-吡咯烷二硫代羧酸铵盐 |
英文名称 | Ammonium 1-pyrrolidinedithiocarbamate |
英文同义词 | 1-Pyrrolidinecarbodithioic acid, ammonium salt,95%;Ammonium Pyrrolidine-N-dithiocarba;PDTC Pyrrolidinedithiocarbamate, ammonium derivative;Ammonium pyrrolidinedithiocarbamate,1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC;Ammonium pyrrolidine;1-Pyrrolidinecarbodithioic acid, aMMoniuM salt, 98% 25GR;Ammonium Pyrrolidine-N-dithiocarbamate 1-Pyrrolidinecarbodithioic Acid Ammonium Salt Pyrrolidine-N-dithiocarbamic Acid Ammonium Salt;PYRROLIDINE-1-DITHIOCARBOXYLIC ACID AMMO |
CAS号 | 5108-96-3 |
分子式 | C5H9NS2.H3N |
分子量 | 164.3 |
EINECS号 | 225-834-4 |
相关类别 | 酶抑制剂;细胞信号和神经生物学;有机原料;医药中间体;细胞生物学;标准品;Nitric Oxide;格氏试剂;生化试剂;化学试剂;中药对照品;生化试剂-其他化学试剂;有机化工原料;合成材料中间体-高分子材料;细胞生物学试剂;化工原料;有机化工原料;通用生化试剂-有机酸 |
Mol文件 | 5108-96-3.mol |
结构式 |
吡咯烷二硫代甲酸铵盐 性质
熔点 | 153-155 °C(lit.) |
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密度 | 1.117 (estimate) |
折射率 | 1.5300 (estimate) |
储存条件 | Store at +2°C to +8°C. |
溶解度 | 190g/l |
形态 | 粉末/固体 |
颜色 | 白色至类白色 |
PH值 | 6-7 (50g/l, H2O, 20℃) |
水溶解性 | 50 g/L (20 ºC) |
敏感性 | Hygroscopic |
BRN | 3730472 |
稳定性 | 稳定的。与强氧化剂不相容。 |
CAS 数据库 | 5108-96-3(CAS DataBase Reference) |
EPA化学物质信息 | 1-Pyrrolidinecarbodithioic acid, ammonium salt (5108-96-3) |
Target | Value |
NF-κB
() |
Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production.
Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA.
Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells.
The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis.
安全信息
危险品标志 | Xi,Xn |
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危险类别码 | 36/37/38-22 |
安全说明 | 26-36-37/39 |
WGK Germany | 3 |
F | 3 |
TSCA | Yes |
海关编码 | 29339990 |
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