PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
中文名称 | PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE |
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中文同义词 | (E)-N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼;WNT/Β-CATENIN通路抑制剂(PNU-74654);N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼;PNU 74654,WNT信号通路阻滞剂;N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼 |
英文名称 | 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide |
英文同义词 | 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654;Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;PNU74654; PNU 74654;CS-2563;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide |
CAS号 | 113906-27-7 |
分子式 | C19H16N2O3 |
分子量 | 320.34 |
EINECS号 | |
相关类别 | 细胞生物学试剂 |
Mol文件 | 113906-27-7.mol |
结构式 |
PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE 性质
密度 | 1.17±0.1 g/cm3(Predicted) |
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储存条件 | 2-8°C |
溶解度 | 二甲基亚砜:>10mg/mL |
酸度系数(pKa) | 12.12±0.46(Predicted) |
形态 | 固体 |
颜色 | 白色至类白色 |
稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 中的溶液可在 -20° 下保存长达 3 个月。 |
129.8 μM (Wnt/β-catenin, NCI-H295 cell)
PNU-74654 binds to β-catenin with a K D of 450 nM. The Tcf3/Tcf4-binding surface on β-catenin contains a well-defined hot spot around residues K435 and R469. The binding mode of PNU-74654 involves the two narrow pockets on either side of this hot spot. In NCI-H295 cells,PNU-74654 significantly decreases cell proliferation 96 h after treatment, increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impairs CTNNB1/beta-catenin expression and increases beta-catenin target genes 48 h after treatment. No effects are observed on HeLa cells. In NCI-H295 cells, PNU-74654 decreases cortisol, testosterone and androstenedione secretion 24 and 48 h after treatment. The SF1 and CYP21A2 mRNA expression as well as the protein levels of STAR and aldosterone synthase are decreased in NCI-H295 cells after 48 h PNU-74654 treatment. In Y1 cells, PNU-74654 impairs corticosterone secretion 24 h after treatment but does not decrease cell viability.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101130 | PNU-74654 | 1 mg | 212元 | |
2024/04/30 | HY-101130 | PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE PNU-74654 | 113906-27-7 | 5mg | 530元 |