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| | KN-92 (hydrochloride) Basic information |
| Product Name: | KN-92 (hydrochloride) | | Synonyms: | KN-92 (hydrochloride);KN92-HCl;KN 92 HYDROCHLORIDE; KN92 HYDROCHLORIDE;CS-1448;Inhibitor,derivative,experimental,inactive,KN-92,KN92 hydrochloride,KN92,inhibit,analog,KN 92 hydrochloride,control,KN 92;N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-4-methoxybenzenesulfonamide hydrochloride | | CAS: | 1431698-47-3 | | MF: | C24H26Cl2N2O3S | | MW: | 493.44584 | | EINECS: | | | Product Categories: | | | Mol File: | 1431698-47-3.mol |  |
| | KN-92 (hydrochloride) Chemical Properties |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | ≥24.65 mg/mL in DMSO; insoluble in H2O; ≥11.73 mg/mL in EtOH with gentle warming and ultrasonic | | form | solid |
| | KN-92 (hydrochloride) Usage And Synthesis |
| Biological Activity | kn-92 is an inactive analog of kn-93. kn-93 is the cam kinase ii inhibitor. [1]hearts were treated with the cam kinase inhibitor kn-93 or the inactive analog kn-92 (0.5 μm) for 10 min before clofilium exposure. early afterdepolarizations (eads) were largely inhibited by kn-93 contrasted to kn-92. there were little differences in parameters favoring eads such as monophasic action potential duration or heart rate in kn-92- or kn-93- treated hearts. cam kinase activity in situ increased 37% in hearts with eads compared to hearts without eads. this increase in cam kinase activity was prevented by pretreatment with kn-93. [1]in vitro, kn-93 potently suppressed rabbit myocardial cam kinase activity (calculated ki ≤ 2.58 μm), but the inactive analog kn-92 did not (ki > 100 μm). the actions of kn-93 and kn-92 on ica and other repolarizing k+currents did not illustrate preferential ead suppression by kn-93. [1] | | references | 1. kn-93, an inhibitor of multifunctional ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. j pharmacol exp ther. 1998 dec;287(3):996-1006. |
| | KN-92 (hydrochloride) Preparation Products And Raw materials |
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