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| 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Basic information |
Product Name: | 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine | Synonyms: | 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine;Cyclopamine inhibitor 1;IRAK inhibitor 1;2-PyridinaMine, 6-iMidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-;2-a]pyridin-3-yl-N-4-piperidinyl-;6-imidazo[1;IRAK inhibitor;IRAK inhibitor 1,Inhibitor,inhibit,Interleukin-1 receptor associated kinase,IL-1R associated kinase,IRAK inhibitor1,IRAK inhibitor-1,IRAK | CAS: | 1042224-63-4 | MF: | C17H19N5 | MW: | 293.37 | EINECS: | | Product Categories: | | Mol File: | 1042224-63-4.mol | |
| 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Chemical Properties |
density | 1.32 | storage temp. | Store at -20°C | solubility | insoluble in EtOH; insoluble in H2O; ≥14.4 mg/mL in DMSO | form | Powder | pka | 9.94±0.10(Predicted) |
| 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Usage And Synthesis |
Biological Activity | the interleukin-1 receptor associated kinase (irak) family is comprised of four family members irak-1, irak-2, irak-3/m, and irak-4. upon activation of their upstream cognate receptors, irak-4 is thought to phosphorylate irak-1 resulting in the activation and autophosphorylation of irak-1 an subsequent phosphorylation of downstream substrates. irak inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (irak-4). | in vitro | the regioisomeric pyridines irak inhibitor 1 (6) and it analogue (7) showed contrasting sar, with the 2,6-pyridine isomer irak inhibitor 1 having low-nanomolar potency whilst the 2,4-pyridine isomer 7 showed little activity, despite having a more accessible bidentate-binding motif. at 10 μm, irak inhibitor 1 was found to have 39% inhibition for jnk-1 and 15% inhibition for jnk-2, respectivley [1]. | target | IRAK-4 | IC 50 | 35 nm for irak-4 | references | [1] buckley gm, ceska ta, fraser jl, gowers l, groom cr, higueruelo ap, jenkins k, mack sr, morgan t, parry dm, pitt wr, rausch o, richard md, sabin v. irak-4 inhibitors. part ii: a structure-based assessment of imidazo[1,2-a]pyridine binding. bioorg med chem lett. 2008;18(11):3291-5. |
| 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Preparation Products And Raw materials |
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