|
|
| Product Name: | E-7449 | | Synonyms: | E7449;E-7449;8-(1,3-dihydro-isoindol-2-ylmethyl)-2,9-dihydro-1,2,7,9-tetraaza-phenalen-3-one;E7449;E 7449;3H-Pyridazino[3,4,5-de]quinazolin-3-one, 8-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-1,2-dihydro-;UNII-9X5A2QIA7C;Stenoparib (E7449);E7449,PARP,Inhibitor,inhibit,E 7449,E-7449,poly ADP ribose polymerase | | CAS: | 1140964-99-3 | | MF: | C18H15N5O | | MW: | 317.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1140964-99-3.mol |  |
| | E-7449 Chemical Properties |
| density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:0.2(Max Conc. mg/mL);0.63(Max Conc. mM) | | form | A crystalline solid | | pka | 9.51±0.20(Predicted) |
| | E-7449 Usage And Synthesis |
| Uses | E 7449 is a dual inhibitor of PARP1/2 and tankyrase1/2 exhibits anti-tumor activity in BRCA-deficient in vivo models. PARP1/2 and tankyrase1/2 are involved with DNA damage and canonical Wnt/β-catenin signaling, respectively. |
| | E-7449 Preparation Products And Raw materials |
|