L-2,4-二氨基丁酸氢溴酸盐

L-2,4-二氨基丁酸氢溴酸盐

中文名称L-2,4-二氨基丁酸氢溴酸盐
中文同义词L-2,4-二氨基丁酸氢溴酸盐;L-2,4-二氨基丁酸氨溴酸盐;L-2,4-二氨基丁酸;L-2,4-二氨基丁酸氢溴酸盐· HCL
英文名称L-DAB HBR
英文同义词L-2,4-DIAMINOBUTYRIC ACID HYDROBROMIDE;L-DAB HBR;L-DAB HYDROBROMIDE;L-2,4-Diaminobutanoate;H-DabHBr;(S)-2,4-Diaminobutyric acid;L-DABA;L-2,4-Diaminobutyric acid hydrobromine
CAS号1758-80-1
分子式C4H10N2O2
分子量118.13
EINECS号
相关类别非天然氨基酸极其衍生物;化学生物学;其他生化试剂;Unusual Amino Acids;Amino hydrochloride
Mol文件1758-80-1.mol
结构式L-2,4-二氨基丁酸氢溴酸盐 结构式

L-2,4-二氨基丁酸氢溴酸盐 性质

熔点216-218 °C
沸点321.0±32.0 °C(Predicted)
密度1.218±0.06 g/cm3(Predicted)
储存条件2-8°C(protect from light)
形态粉末
酸度系数(pKa)2.00±0.10(Predicted)
CAS 数据库1758-80-1(CAS DataBase Reference)

L-2,4-二氨基丁酸氢溴酸盐 用途与合成方法

L-DABA (L-2,4-Diaminobutyric acid)是GABA转氨酶的弱抑制剂,IC50 值大于500 μM。在体内和体外具有抗肿瘤活性。

Human Endogenous Metabolite

The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA. The harmful effect of L-DABA could be abolished by concomitant incubation with L-alanine and L-methionine. Kinetic studies indicates that L-DABA is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line.

Treatment with L-DABA results in 43.4% reduction of tumor growth. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro .

安全信息

海关编码2922498590

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-101414L-2,4-二氨基丁酸氢溴酸盐
L-DABA
1758-80-1100mg500元

L-2,4-二氨基丁酸氢溴酸盐 上下游产品信息

"L-2,4-二氨基丁酸氢溴酸盐"相关产品信息
6-异氰酸基-1,4-苯并二噁烷 2,4-二氯苯基异氰酸酯 FMOC-DAP(MTT)-OH FMOC-D-DAP(ALLOC)-OH N-芴甲氧羰基-[N'-1-(4,4-二甲基-2,6-二氧代环己-1-亚基)乙基]-D-2,3-二氨基丙酸 N-芴甲氧羰基-3-[[(烯丙氧基)羰基]氨基]-L-丙氨酸 FMOC-D-DAP(IVDDE)-OH N/A N2-芴甲氧羰基-N3-叔丁氧羰基-D-2,3-二氨基丙酸 2,4-二氨基丁酸盐酸盐 FMOC-DOPA(ACETONIDE)-OH FMOC-D-DAP(MTT)-OH FMOC-D-DAP(AC)-OH 3-(乙酰氨基)-N-[芴甲氧羰基]-L-丙氨酸 2,4-二氨基丁酸 L-2,4-二氨基丁酸氢溴酸盐 N-[4-(2-溴-4,5-二氟苯氧基)苯基]-L-天冬酰胺
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