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MAK-683

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MAK-683 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:MAK-683
CAS:1951408-58-4
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:MAK683
CAS:1951408-58-4
Purity:98% Package:5mg Remarks:BOC Sciences also provides custom synthesis services for MAK683.
Company Name: Neostar United (Changzhou) Industrial Co., Ltd.
Tel: +86-519-519-85557386
Email: marketing1@neostarunited.com
Products Intro: Product Name:MAK683
CAS:1951408-58-4
Package:1KG;5KG;100KG;1000KG
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:MAK683
CAS:1951408-58-4
Purity:98.00% Package:10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:MAK683
CAS:1951408-58-4
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
MAK-683 Basic information
Product Name:MAK-683
Synonyms:CPD 1111;MAK-683;EED inhibitor-1;MAK 683;MAK-683;MAK683;N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine;N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID;1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-;inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683
CAS:1951408-58-4
MF:C20H17FN6O
MW:376.39
EINECS:
Product Categories:
Mol File:1951408-58-4.mol
MAK-683 Structure
MAK-683 Chemical Properties
density 1.47±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 15 mg/ml
form A solid
pka2.70±0.12(Predicted)
Safety Information
MSDS Information
MAK-683 Usage And Synthesis
DescriptionMAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED). MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC50 = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC50 value of 3 nM.
UsesMAK-683 is a useful intermediate for the preparation of triazolopyrimidine compounds useful in the treatment of diseases or disorders mediated by EED and/or PRC2. EED inhibitor-1.
MAK-683 Preparation Products And Raw materials
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