| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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| Products Intro: |
Product Name:Thymidine Phosphorylase, recombinant from Escherichia coli
CAS:9030-23-3
Purity:recombinant, expressed in E. coli, buffered aqueous solution Package:1KU Remarks:T2807-1KU
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| Company Name: |
Guangzhou Tomums Life Science Co., Ltd.
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020-31155029 18902330969 |
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sales@tomums.cn |
| Products Intro: |
Product Name:Thymidine Phosphorylase, recombinant from Escherichia coli
CAS:9030-23-3
Package:5KU
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| | EC 2.4.2.4 Basic information |
| Product Name: | EC 2.4.2.4 | | Synonyms: | EC 2.4.2.4;THYMIDINE PHOSPHORYLASE FROM*ESCHERICHIA COLI;THYMIDINE PHOSPHORYLASE, RECOMBINANT*FRO M E. COLI;THYMIDINE PHOSPHORYLASE, ASEPTICALLY*FIL LED, FROM E;thymidine:orthophosphate deoxy-d-ribosyltransferase;Thymidine Phosphorylase, recombinant from Escherichia coli;MNGIE;ANTI-ECGF1 (CENTER) antibody produced in rabbit | | CAS: | 9030-23-3 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![EC 2.4.2.4 Structure]() |
| | EC 2.4.2.4 Chemical Properties |
| storage temp. | 2-8°C | | form | buffered aqueous solution |
| | EC 2.4.2.4 Usage And Synthesis |
| Uses | Thymidine phosphorylase has been used in a study to assess TAS-102 treatment in patients with advanced solid tumors. Thymidine phosphorylase has also been used in a study to investigate antitumor effects of the FP3 protein on patient-derived tumor tissue xenograft models of primary colon carcinoma. | | Uses | Thymidine phosphorylase has been used in a study to evaluate biomarkers for advanced breast cancer patients treated with capecitabine-based first-line chemotherapy. Thymidine phosphorylase has also been used in a study to investigate implications for the clinical efficacy of nucleoside analogues. | | General Description | Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation. | | Biochem/physiol Actions | An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. The E. coli thymidine phosphorylase shares 40% sequence homology with the human sequence, which has been found to be identical to the angiogenic agent platelet-derived endothelial growth factor. The purified E. coli enzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays. |
| | EC 2.4.2.4 Preparation Products And Raw materials |
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