高良姜素
中文名称 | 高良姜素 |
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中文同义词 | 3,5,7-三羟基黄酮;高良姜精;高良姜素;GALANGIN 高良姜素;3,5,7-三羟基-2-苯基-4H-苯并吡喃-4-酮;高良姜素(高良姜精,高良姜黄素,3,5,7-三羟基黄酮);高良姜素, 来源于高良姜;高良姜精,高良姜黄素,3,5,7-三羟基黄酮 |
英文名称 | Galangin |
英文同义词 | 4H-1-Benzopyran-4-one,3,5,7-trihydroxy-2-phenyl;Galengin;3,5,7-Trihydroxy-2-phenyl-4h-benzopyran-4-one;3,5,7-Trihydroxy-2-phenyl-4H-chroMen-4-one;Galangin, froM Alpinia officinaruM;Galangin, >=98%;GALANGIN, AUTOPHAGY INDUCING FLAVONO;3,5,7-trihydroxy-2-phenyl-4h-benzopyran-4-on |
CAS号 | 548-83-4 |
分子式 | C15H10O5 |
分子量 | 270.24 |
EINECS号 | 208-960-4 |
相关类别 | 芳烃衍生物;杂环;植物提取物;中药对照品;标准品;分析标准品;植提标准品;对照品;植物生化提取物;中药标准品;标准品-中药标准品;Flavanols;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Antineoplastic;分析对照品;分析试剂标准品;标准品-对照品;有机原料;标准品,对照品;黄酮;标准品 -中药标准品;分析试剂-对照品;医药原料 |
Mol文件 | 548-83-4.mol |
结构式 |
高良姜素 性质
熔点 | 214-215 °C(lit.) |
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沸点 | 333.35°C (rough estimate) |
密度 | 1.2319 (rough estimate) |
折射率 | 1.6000 (estimate) |
储存条件 | room temp |
溶解度 | 可溶于丙酮(少许)、乙酸乙酯(少许) |
形态 | 固体 |
酸度系数(pKa) | 6.32±0.40(Predicted) |
颜色 | 浅黄色至厚黄色 |
Merck | 14,4339 |
BRN | 272179 |
InChIKey | VCCRNZQBSJXYJD-UHFFFAOYSA-N |
LogP | 3.322 (est) |
CAS 数据库 | 548-83-4(CAS DataBase Reference) |
Galangin (Norizalpinin) inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth. Galangin causes a potent, dose-dependent inhibition of CYP1A1 activity, as measured by ethoxyresorufin-O-deethylase activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that galangin inhibits CYP1A1 activity in a noncompetitive manner. Galangin causes an increase in the level of CYP1A1 mRNA, indicating that it may be an agonist of the aryl hydrocarbon receptor, but it inhibits the induction of CYP1A1 mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD). Galangin also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the CYP1A1 promoter. Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level.
药理药效:具有抗病毒作用,能使鼠伤寒沙门氏菌TA98和TA100发生诱变。
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