9,10-didehydro-6-methylergoline-8beta-carboxamide

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9,10-didehydro-6-methylergoline-8beta-carboxamide Basic information
Product Name:9,10-didehydro-6-methylergoline-8beta-carboxamide
Synonyms:9,10-didehydro-6-methylergoline-8beta-carboxamide;Ergoline-8-carboxamide, 9,10-didehydro-6-methyl-, (8β)-;Methylergometrine Maleate - Impurity C;Methylergometrine Impurity C
CAS:478-94-4
MF:C16H17N3O
MW:267.33
EINECS:2075240
Product Categories:Amines;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:478-94-4.mol
9,10-didehydro-6-methylergoline-8beta-carboxamide Structure
9,10-didehydro-6-methylergoline-8beta-carboxamide Chemical Properties
Melting point >200°C (dec.)
alpha 205461 +15° (c = 0.5 in pyridine)
Boiling point 410.51°C (rough estimate)
density 1.0724 (rough estimate)
refractive index 1.7210 (estimate)
storage temp. Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly)
form Solid
pka15.87±0.20(Predicted)
color Pale Brown to Brown
Safety Information
ToxicityTDLo oral in human: 14ug/kg
DEA Controlled SubstancesCSCN: 7310
CSA SCH: Schedule III
NARC: No
MSDS Information
9,10-didehydro-6-methylergoline-8beta-carboxamide Usage And Synthesis
Chemical PropertiesBrown Solid
UsesAn alkaloid in abundance in tall fescue, resulted in vasoconstriction similar to that previously shown for the ergot alkaloids ergonovine and ergotamine.
DefinitionChEBI: An ergoline alkaloid comprising ergoline lacking hydrogens at positions 9 and 10 and also having a methyl group attached to the piperidine nitrogen.
Purification MethodsThe (-)-hydrochloride has m 208-210o(dec, from MeOH). [Kornfeld et al. J Am Chem Soc 76 5256 1954, Kornfeld et al. J Am Chem Soc 78 3087 1956, Beilstein 25 III/IV 934,]
9,10-didehydro-6-methylergoline-8beta-carboxamide Preparation Products And Raw materials
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