光辉霉素
中文名称 | 光辉霉素 |
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中文同义词 | 光辉霉素;光神霉素A;光辉酶素,光神霉素,普芳拉星,金霉酸;光神霉素,光辉霉素A;光辉霉素A;金霉酸;光辉酶素;光神霉素 |
英文名称 | MITHRAMYCIN A |
英文同义词 | AUREOLIC ACID;METHRAMYCIN A;MITHRAMYCIN A, FOR FLUORESCENCE;MITHRAMYCIN A FROM STREPTOMYCES*PLICATUS APPROX. 96;MITHRAMYCIN COMPLEX FROM STREPTOMYCES*PL ICATUS;MITHRAMYCIN FROM STREPTOMYCES PLICATUS;MITHRACIN;MITHRAMYCIN A |
CAS号 | 18378-89-7 |
分子式 | C52H76O24 |
分子量 | 1085.15 |
EINECS号 | 634-048-4 |
相关类别 | 医药原料药;抗生素类;抗生素、生物碱;抗生素及抗病毒;生化试剂;抗生素;微生物代谢物;Antibiotics;Antitumour;antibiotic;医药原料;通用生化试剂-抗生素;试剂盒-细胞分析试剂盒;科研精品试剂;化学试剂;对照品 |
Mol文件 | 18378-89-7.mol |
结构式 |
光辉霉素 性质
熔点 | 180-183 °C |
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比旋光度 | D20 -51° (c = 0.4 in ethanol) |
沸点 | 761.72°C (rough estimate) |
密度 | 1.1576 (rough estimate) |
折射率 | 1.6500 (estimate) |
储存条件 | 2-8°C |
溶解度 | 可溶于DMSO(高达20mg/ml)或乙醇(高达10mg/ml) |
形态 | 粉末 |
酸度系数(pKa) | 4.54±0.60(Predicted) |
颜色 | 红色至棕色 |
Merck | 13,7619 |
BRN | 5236667 |
稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 或乙醇溶液可在 -20°C 下保存长达 1 个月。 |
EPA化学物质信息 | Plicamycin (18378-89-7) |
Sp1 transcription factor
Sp1 is a zinc-finger transcription factor that regulates multiple cellular functions and promotes tumor progression by controlling expression of genes involved in cell cycle, apoptosis and DNA damage. Sp1 binds to GC-rich motifs of promoters and interacts with components of the general transcriptional machinery and co-activator complexes of multiple signaling pathways. Plicamycin (Mith) decreases Sp1 protein by inducing proteasome-dependent degradation, thereby suppressing cervical cancer growth through a DR5/caspase-8/Bid signaling pathway. To assess the antiproliferative effects of Plicamycin on cervical cancer cells, two cervical cancer cell lines with different genetic backgrounds are grown with or without treatment with Plicamycin at different concentrations. Plicamycin inhibits HEp-2 and KB cell growth in a concentration-dependent manner after 48 h. Apoptotic cell death is qualitatively estimated by DAPI staining for nuclear condensation and fragmentation. Plicamycin leads to significant DNA fragmentation compared to untreated controls.
The antitumorigenic activity of Plicamycin (0.2 mg/kg/day) is determined in a xenograft model and observed reduction in tumor volume and weight. No significant mouse body weight loss is observed in Plicamycin-treatment groups, indicating that Plicamycin-associated toxicity is minimal. Plicamycin also increases TUNEL-positive cells in tumor xenografts. No notable intergroup differences are observed among organs, indicating no marked signs of systemic toxicity at the Plicamycin dose used in this study.
安全信息
危险品标志 | Xn,T+ |
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危险类别码 | 22-26/27/28 |
安全说明 | 45-38-36/37/39-28A-22 |
危险品运输编号 | 3249 |
WGK Germany | 3 |
RTECS号 | PZ2800000 |
F | 10 |
危险等级 | 6.1(b) |
包装类别 | III |
海关编码 | 29419090 |
毒害物质数据 | 18378-89-7(Hazardous Substances Data) |
毒性 | LD50 in mice, rats (mg/kg): 2.14, 1.74 i.v. (Slavik, Carter) |
提供商 | 语言 |
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英文
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-A0122 | 光辉霉素 Plicamycin | 18378-89-7 | 1 mg | 1244元 |
2024/08/19 | HY-A0122 | Plicamycin | 2 mg | 1990元 |