利马前列素
中文名称 | 利马前列素 |
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中文同义词 | (2E,11Α,13E,15S,17S)-11,15-二羟基-17,20-二甲基-9-氧代前列-2,13-二烯-1-酸(2E,11Α,13E,15S,17S)-11,15-DIHYDROXY-17,20-DIMETHYL-9-OXOPROSTA-2,13-DIEN-1-OICACID;利马前列;利马司特;利马前列素;利马前列素(干冰运输);利马前列素/利马斯特;立马前列素;(E)-7-((1R,2R,3R)-3-羟基-2-((3S,5S,E)-3-羟基-5-甲基壬-1-烯-1-基)-5-氧代环戊基)庚-2-烯酸 |
英文名称 | LIMAPROST |
英文同义词 | (2e,11-alpha,13e,15s,17s)-11,15-dihydroxy-17,20-dimethyl-9-oxoprost-2,13-die;,13e,15s,17s)-;11α,15s-dihydroxy-17s,20-dimethyl-9-oxo-prosta-2e,13e-dien-1-oic acid;17S,20-Dimethyl-trans-D2-PGE1;2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-, (2E)- (9CI);Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11a,13E,15S,17S)-;17α,20-dimethyl-δ2-PGE1, 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid;(2E)-7-[(1R)-2β-[(1E,3S,5S)-3-Hydroxy-5-methyl-1-nonenyl]-3α-hydroxy-5-oxocyclopentan-1α-yl]-2-heptenoic acid |
CAS号 | 74397-12-9 |
分子式 | C22H36O5 |
分子量 | 380.52 |
EINECS号 | |
相关类别 | 药物;合成;原料药;激素及其有关药物;前列腺素;有机原料;医药原料药;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 74397-12-9.mol |
结构式 |
利马前列素 性质
熔点 | 97-100° |
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沸点 | 550.6±50.0 °C(Predicted) |
密度 | 1.118 |
储存条件 | -20°C |
溶解度 | 在DMF中可溶 |
形态 | 结晶 |
酸度系数(pKa) | 4.78±0.10(Predicted) |
颜色 | 白色至米白色 |
Limaprost inhibits the IL-1-mediated induction of nerve growth factor (NGF) in a concentration-dependent manner with an IC 50 value of 70.9 nM human IVD cells.
Limaprost (OP1206) given orally at more than 100 mg/kg relieves Argipressin-induced ST depression of rat electrocardiogram (ECG).
Intra-coronary injection of Limaprost (OP1206; 1-100 ng/kg) in dogs results in a remarkable increase of coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption and redox potential.
Resistance in both large and small vessels of dog coronary artery is decreased by intravenous injection of Limaprost (OP1206; 1-3 mg/kg).
Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost (OP1206) at the same doses or doses less than those relieving Argipressin-induced ST depression of ECG.
安全信息
危险品标志 | T |
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危险类别码 | 25 |
安全说明 | 36/37/39-45 |
危险品运输编号 | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS号 | UK8362500 |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-B0683 | 利马前列素 Limaprost | 74397-12-9 | 2mg | 1200元 |
2024/08/19 | HY-B0683 | 利马前列素 Limaprost | 74397-12-9 | 10mM * 1mLin DMSO | 1993元 |