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RAS-2410 hydrochloride

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RAS-2410 hydrochloride Suppliers list
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:RAS-2410 hydrochloride
CAS:1187075-34-8
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: ANHUI WITOP BIOTECH CO., LTD
Tel: +8615255079626
Email: eric@witopchemical.com
Products Intro: Product Name:RAS-2410 hydrochloride
CAS:1187075-34-8
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:RAS-2410 hydrochloride
CAS:1187075-34-8
Purity:99% Package:5KG;1KG Remarks:RAS-2410 hydrochloride
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Resminostat HCl
CAS:1187075-34-8
Purity:98% Package:5mg Remarks:V3846
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:Resminostat hydrochloride；RAS2410 hydrochloride;4SC-201 hydrochloride
CAS:1187075-34-8
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

RAS-2410 hydrochloride manufacturers

  • RAS-2410 hydrochloride
  • RAS-2410 hydrochloride pictures
  • $0.00 / 1gram
  • 2022-02-19
  • CAS:1187075-34-8
  • Min. Order: 1gram
  • Purity: 99%
  • Supply Ability: 10kg
RAS-2410 hydrochloride Basic information
Product Name:RAS-2410 hydrochloride
Synonyms:4SC-201 hydrochloride;RAS 2410 hydrochloride;RAS2410 hydrochloride;RAS-2410 hydrochloride;ResMinostat (hydrochloride);(2E)-3-[1-[[4-[(Dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide hydrochloride (1:1);Resminostat HCl;RAS2410; 4SC-201; RAS 2410; RAS-2410;4SC201;4SC 201
CAS:1187075-34-8
MF:C16H20ClN3O4S
MW:385.8657
EINECS:
Product Categories:APIs
Mol File:1187075-34-8.mol
RAS-2410 hydrochloride Structure
RAS-2410 hydrochloride Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form crystalline solid
Safety Information
MSDS Information
RAS-2410 hydrochloride Usage And Synthesis
DescriptionResminostat is an orally bioavailable inhibitor of histone deacetylase 1 (HDAC1), HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells. It abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 μM). Resminostat displays synergistic effects when combined with melphalan and the proteasome inhibitors bortezomib and S-2209. It dose-dependently inhibits HDAC activity in vivo.
references[1] mandl-weber s, meinel fg, jankowsky r, oduncu f, schmidmaier r, baumann p. the novel inhibitor of histone deacetylase resminostat (ras2410) inhibits proliferation and induces apoptosis in multiple myeloma (mm) cells. br j haematol. 2010 may;149(4):518-28.
[2] brunetto at, ang je, lal r, olmos d, molife lr, kristeleit r, parker a, casamayor i, olaleye m, mais a, hauns b, strobel v, hentsch b, de bono js. first-in-human, pharmacokinetic and pharmacodynamic phase i study of resminostat, an oral histone deacetylase inhibitor, in patients with advanced solid tumors. clin cancer res. 2013 oct 1;19(19):5494-504.
RAS-2410 hydrochloride Preparation Products And Raw materials
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