劳丹素(半日花素)
中文名称 | 劳丹素(半日花素) |
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中文同义词 | 劳丹素;DL-劳丹素/半日花素;N-甲四氫罌粟鹼;勞丹辛;劳丹素(半日花素);劳丹素 EP标准品;阿曲库铵杂质49;苯磺酸顺阿曲库铵杂质47 |
英文名称 | DL-Laudanosine |
英文同义词 | (+-)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinoline;(+-)-laudanosine;2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratryl-(+-)-isoquinolin;N-METHYLTETRAHYDROPAPAVERINE;DL-LAUDANOSIDE;DL-LAUDANOSINE;(+/-)-LAUDANOSIDE;LAUDANOSINE, DL- |
CAS号 | 1699-51-0 |
分子式 | C21H27NO4 |
分子量 | 357.44 |
EINECS号 | 216-923-9 |
相关类别 | 植物提取物;顺苯磺酸阿曲库铵杂质 |
Mol文件 | 1699-51-0.mol |
结构式 |
劳丹素(半日花素) 性质
熔点 | 115°C |
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沸点 | 490.07°C (rough estimate) |
密度 | 1.1729 (rough estimate) |
折射率 | 1.5614 (estimate) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:100 mg/mL(279.77 mM) |
形态 | 固体 |
酸度系数(pKa) | 7.80±0.40(Predicted) |
颜色 | 白色至浅米色 |
InChI | InChI=1S/C21H27NO4/c1-22-9-8-15-12-20(25-4)21(26-5)13-16(15)17(22)10-14-6-7-18(23-2)19(11-14)24-3/h6-7,11-13,17H,8-10H2,1-5H3 |
InChIKey | KGPAYJZAMGEDIQ-UHFFFAOYSA-N |
SMILES | C1(CC2=CC=C(OC)C(OC)=C2)C2=C(C=C(OC)C(OC)=C2)CCN1C |
LogP | 3.630 (est) |
DL-Laudanosine 是 Atracurium 和 Cisatracurium 的代谢物,可透过血脑屏障,引起兴奋和癫痫发作。
DL-Laudanosine (Laudanosine) appears to be unique in its ability to produce cerebral stimulation in lightly anaesthetized animals and it is reported to cause arousal from anaesthesia in subconvulsive doses.
Animal Model: | Male CFLP mice weighing 18-25 g, and male Wistar rats weighing 120-150 g . |
Dosage: | 10-20 mg/kg. |
Administration: | IV. |
Result: | Caused convulsions and hind limb extensions. |
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