Product Details
| Product Name:
Benzonatate |
CAS No.:
104-31-4 |
| Min. Order:
1g |
Purity:
96%-99% |
| Supply Ability:
1kg/10kg/100kg |
Release date:
2021/01/06 |
Email: amy@coreychem.com
Career Henan Chemical Co
Mob/Skype: +86-18317388371
| Benzonatate Basic information |
| Product Name: |
Benzonatate |
| Synonyms: |
4-(Butylamino)benzoicacid3,6,9,12,15,18,21,24,27-nonaoxao-ctacos-1-ylester;benzoicacid,4-(butylamino)-,3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yles;benzononantin;benzononatine;tessalon;tessalon-ciba;thoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethylester;ventussin |
| CAS: |
104-31-4 |
| MF: |
C30H53NO11 |
| MW: |
603.74 |
| EINECS: |
203-194-7 |
| Product Categories: |
Chemical Amines;Amines;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: |
104-31-4.mol |
 |
| |
| Benzonatate Chemical Properties |
| Boiling point |
649.0±55.0 °C(Predicted) |
| density |
1.096±0.06 g/cm3(Predicted) |
| pka |
2.20±0.39(Predicted) |
| CAS DataBase Reference |
104-31-4(CAS DataBase Reference) |
| Toxicity |
LD50 oral in mouse: 400mg/kg |
| |
| Benzonatate Usage And Synthesis |
| Originator |
Tessalon,Endo (Du Pont),US,1958 |
| Uses |
Antitussive |
| Definition |
ChEBI: The ester obtained by formal condensation of 4-butylaminobenzoic acid with nonaethylene glycol monomethyl ether. Structurally related to procaine and benzocaine, it has an anaesthetic effect on the stretch sensors in the lungs, and is used as a non-narcoti cough suppressant. |
| Manufacturing Process |
4.42 parts of para-butylamino-benzoic acid ethyl ester are put with 16.0 parts of a mixture of polyethylene glycol monomethyl ethers, boiling at 180°-220°C at a pressure of 0.01 mm of mercury, in a closed reaction vessel which is fitted with an adjustable inlet tube for solvents and a connection for distilling off in vacuo. In order to dry the mixture completely, it is heated for an hour at 100°-105°C and absolute xylene is introduced under the surface of the mixture in vacuo at a pressure of 12 mm of mercury. There is thus a constant stream of xylene steam passing through the whole apparatus, which removes the last traces of moisture and any other volatile impurities. The xylene is condensed in a cooler. The whole is cooled to 20°-30°C and 0.06 part of sodium methylate dissolved in 0.6 part of methanol is added.
Thereupon xylene is introduced again in vacuo at a temperature of 100°- 105°C whereby all the methanol and the ethanol formed during reesterification evaporates. The re-esterification is continued under these conditions until a specimen of the reaction mass is clearly soluble in cold water, which occurs after about 2-3 hours. There is now obtained in almost quantitative yield the ester of the formula wherein n stands for approximately 7 to 9, which still contains an excess of polyethylene glycol monomethyl ether. The ester is purified by dissolving in benzene and being washed several times with a sodium carbonate solution of 5% strength. It is advantageous to agitate all the washing solutions with fresh benzene. In this distribution between benzene and sodium carbonate solution the new ester remains in the benzene, the excess polyethylene glycol monomethyl ether and a small amount of brown impurities are taken up by the dilute soda solution. By evaporating the dried and filtered benzene solution there is obtained the new ester in the form of a colorless to very faintly yellow oil which is easily soluble in most organic solvents with the exception of aliphatic hydrocarbons. The new ester is precipitated from aqueous solutions when heated to about 42°C. but it dissolves again readily on cooling. |
| Brand name |
Tessalon (Forest). |
| Therapeutic Function |
Antitussive |
| Biological Functions |
Benzonatate (TessaIon) is related to the local anesthetic tetracaine. It anesthetizes the stretch receptors in the lungs, thereby reducing coughing.Adverse reactions include hypersensitivity, sedation, dizziness, and nausea. |
| |
| Benzonatate Preparation Products And Raw materials |
| Raw materials |
1-Bromobutane-->Benzocaine-->Methoxypolyethylene glycols-->NONAETHYLENE GLYCOL MONOMETHYL ETHER-->Ethyl 4-(butylamino)benzoate |
Company Profile Introduction
Technology research and transfer of pilot screening, pilot scale-up and mass production solutions , for pharmaceutical intermediates, biologicals and fine chemicals (Not including inflammable , explosive , hazardous goods ) ; Market : Nano material , metal catalyst , raw material of cosmetics , pharmaceutical intermediates , chemicals , photoelectric material , import and export of technology and goods (For projects subject to approval according to law, business activities can be carried out only after approval by relevant departments ).
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$15.00/1KG |
|
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-08-10 |
|
|
$1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2021-06-10 |
China