4,4'-Dimethyldiphenylsulfoxide

4,4'-Xylylene sulfoxide is a sulfoxide compound. Representative listed drugs containing sulfoxide skeleton structure such as esomeprazole (A.Aktiebolag, US5877192A, 1998) for the treatment of stomach and modafinil for the treatment of narcolepsy and anorexia (L.L.Lafon) , US4927855A, 1990). Due to its structural diversity and remarkable biological functions, the synthesis of sulfoxides has attracted extensive attention from synthetic organic chemists and pharmacologists. In addition, sulfoxide compounds also have important biological activities. By modifying the structure of sulfoxide chemicalbook compounds, their pharmacodynamic activities can be improved, such as anti-ulcer, anti-virus, anti-HIV-1, anti-tumor and so on. In the field of pesticides, sulfoxide compounds have the advantages of low dosage and low pollution as fungicides and herbicides. Sulfoxide compounds contain semi-polar groups, so they are a kind of soft base neutral extractant and have special affinity for precious metals in soft acids, so they have high extraction rate and good selectivity for precious metals. At the same time, sulfoxide is an important part of many natural products and pharmaceutical intermediates. Therefore, it is of great significance to develop efficient and fast methods for synthesizing sulfoxide, and it is also a hot research field.

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