5-Aminolevulinic acid hydrochloride NEW

Factory Provide Sport Nutrition CAS 5451-09-2 5-Aminolevulinic Acid Hydrochloride/5-Ala HCl

Introduction

Product Name : 5-Aminolevulinic acid hydrochloride

Othe name :5-Aminolevulinic acid Hcl;5-Ala HCl

CAS No. 5451-09-2

Molecular Formula: C5H10ClNO3

MW: 167.59

Assay: 99%
Appearance: White powder
Melting Point :~150 °C (dec.)

Boiling Point :155-157°C

Solubility:Soluble in dimethyl sulfoxide, methanol and water.

Storage :Sealed in dry,Room Temperature

5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.Target: Others5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique

1.Applied in the pharmaceutical field, 5-Aminolevulinic acid/5-ala mainly used as photosensitizer;
2.Applied in the agriculture field, 5-Aminolevulinic acid/5-ala used as herbicide and pesticide;
3.Applied in cosmetics field, it used as raw materials to improve skin aging and remove the acne and spot.