Product Details
| Product Name:
Chelerythrine chloride |
CAS No.:
34316-15-9 |
| Min. Order:
1 mg |
Purity:
99% |
| Supply Ability:
100KG |
Release date:
2019/07/06 |
| Product :
AD |
| Chelerythrine chloride Basic information |
| Description References |
| Product Name: |
Chelerythrine chloride |
| Synonyms: |
CHELERYTHRINE(TODDALINE)(RG);1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium;1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride;Chelerythrine chloride;1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium;Cheleritrine;3895-92-9 (Chloride) |
| CAS: |
34316-15-9 |
| MF: |
C21H18NO4+ |
| MW: |
348.37192 |
| EINECS: |
251-930-0 |
| Product Categories: |
Natural Plant Extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: |
34316-15-9.mol |
 |
| |
| Chelerythrine chloride Chemical Properties |
| Melting point |
195-205°C |
| Boiling point |
496.37°C (rough estimate) |
| density |
1.2985 (rough estimate) |
| refractive index |
1.5614 (estimate) |
| storage temp. |
Desiccate at -20°C |
| CAS DataBase Reference |
34316-15-9(CAS DataBase Reference) |
| Hazard Codes |
Xn |
| Risk Statements |
20/21/22 |
| Safety Statements |
36/37 |
| |
| Chelerythrine chloride Usage And Synthesis |
| Description |
Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad. |
| References |
https://en.wikipedia.org/wiki/Chelerythrine
https://www.scbt.com/scbt/product/chelerythrine-chloride-3895-92-9
https://www.tocris.com/dispprod.php?ItemId=2342#.WQmZVVNsgZQ |
| Definition |
ChEBI: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. |
| Biological Activity |
Potent, cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis. |
| Purification Methods |
Chelerythrine crystallises from CHCl3 on addition of MeOH [Manske Can J Res 21B 140 1943, UV: Hruban et al. Coll Czech Chem Commun 35 3420 1970]. The pseudo base is colourless while the salts are yellow in aqueous solution and are fluorescent. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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