PeraMpanel

Price	$7
Package	1KG

Product Details

Product Name: PeraMpanel	CAS No.: 380917-97-5
Min. Order: 1KG	Purity: 99%
Supply Ability: JD 474	Release date: 2019/09/02

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Product Name:

PeraMpanel

Synonyms:

PeraMpanel;E 2007;ER 155055-90;PeraMpanel-D5;PeraMpanel-13C6;3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one;3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one;2-(2-oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile

CAS:

380917-97-5

MF:

C23H15N3O

MW:

349.3847

EINECS:

691-969-4

Product Categories:

API;Inhibitors;-

Mol File:

380917-97-5.mol

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PeraMpanel Chemical Properties

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Safety Information

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MSDS Information

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PeraMpanel Usage And Synthesis

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Description

Perampanel (licensed in 2012) is a third- generation AED known with the proprietary brand name of Fycompa® (Eisai, Hatfield) in the UK and Banzel® (Eisai, Hatfield) in the USA.

Indications

Epilepsy: Adjunctive treatment of focal seizures with or without secondary generalization and primary generalized tonic- clonic seizures.

Dose titration

Epilepsy— adjunctive therapy: 2 mg nocte for at least 14 days, then increased by 2 mg every 14 or more days; usual maintenance 4– 8 mg nocte (max. 12 mg nocte).

Interactions

With AEDs

Some AEDs known as CYP450 3A enzyme inducers (carbamazepine, oxcarbazepine, phenytoin) have been shown to increase perampanel clearance and consequently to decrease plasma concentrations of perampanel. Carbamazepine, a known potent enzyme inducer, reduced perampanel levels by two- thirds in a study performed on healthy subjects
In the epilepsy population pharmacokinetic analysis, perampanel was found to decrease the clearance of oxcarbazepine by 26%. Oxcarbazepine is rapidly metabolized by cytosolic reductase enzyme to the active metabolite, monohydroxycarbazepine. The effect of perampanel on monohydroxycarbazepine concentrations is not known.

With other drugs

Strong inducers of cytochrome P450, such as rifampicin and St John’s Wort (Hypericum perforatum), are expected to decrease perampanel concentrations.
In healthy subjects, the CYP3A4 inhibitor ketoconazole increases perampanel exposure.
Perampanel can make certain hormonal contraceptives such as levonorgestrel less effective.
Decrease in exposure of midazolam may be caused by perampanel.

With alcohol/food

Drinking alcohol while taking perampanel can affect a patients’ alertness and ability to drive or use tools or machines. It can also aggravate irritability, confusion, and depression.
There are no specific foods that must be excluded from diet when taking perampanel.

Special populations

Hepatic impairment

Increase at intervals of at least 2 weeks, up to a maximum of 8 mg daily, in mild- to- moderate impairment.
Avoid in severe impairment.

Renal impairment
Avoid in moderate or severe impairment.

Pregnancy

There are limited amount of data available on the use of perampanel in pregnant women and the potential risk for humans is unknown.
Perampanel is not recommended in pregnancy and female patients must use a reliable method of contraception to avoid becoming pregnant while being treated with perampanel (this should be continued for 1 month after stopping treatment).
As perampanel can make certain hormonal contraceptives such as levonorgestrel less effective, other forms of safe and effective contraception (such as a condom or coil) should be used when taking perampanel (this should be continued for 1 month after stopping treatment).
Perampanel has been found to be present in milk in animal studies and it is recommended that breastfeeding should be avoided.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

Recommended supplier

Product name	Price		Suppliers	Update time
PeraMpanel	$0.00/1kg	VIP2Y	Nanjing Kaitian Chemical Co., LTD	2023-02-10
PeraMpanel	$0.00/25kg		PNP Biotech Co. Ltd	2022-09-16
Perampanel	$0.00/25kg		Zhejiang Hengkang Pharmaceutical Co., Ltd.	2022-09-02
Perampanel-D5	$0.00/5mg		Simson Pharma limited	2022-07-29
Perampanel	$15.00/1KG		Zhuozhou Wenxi import and Export Co., Ltd	2021-07-10
Perampanel	$15.00/1KG		Zhuozhou Wenxi import and Export Co., Ltd	2021-07-09

Product Details

Company Profile Introduction

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career henan chemical co