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Postion:Product Catalog >API>Circulatory system drugs>Angina Pectoris Drugs>Amlodipine Besylate
Amlodipine Besylate
  • Amlodipine Besylate

Amlodipine Besylate

Price Get Latest Price
Package 1Kg/Bag
Min. Order: 5g
Supply Ability: 800 kg
Update Time: 2019-09-18

Product Details

Product Name: Amlodipine Besylate CAS No.: 111470-99-6
EC-No.: 1312995-182-4 Min. Order: 5g
Purity: 99% Supply Ability: 800 kg
Release date: 2019/09/18
MF: C26H31ClN2O8S

CAS 111470-99-6

 

 

Product Name

Amlodipine besilate

Alias

mono benzene sulfonate

CAS

111470-99-6

MF

C26H31ClN2O8S

MW

567.05

Purity

99%

Appearance

White Crystalline Solid

Certification

ISO 9001, USP, BP

Standard

BP Standard

Usage

A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive

Packing

Discreet packing ways as your requirement, 100% go through

Storage

Store in cool and dry area and keep away from direct sunlight

 

 

 

Specification:

Item

Specification

 

Result

Appearance

White or almost white powder

 

Complies

Identification

IR spectrum is in conformance with that of RSThe retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the assay

Complies

Optical rotation

-0.10°~+0.10°

 

+0°

Water

≤0.5%

 

0.10%

Residue on ignition

≤0.02%

 

0.004%

Related substances

TLC method: any impurity ≤0.3%, at most 2 impurities more than 0.1%

Complies

HPLC method: amlodipine impurity A ≤0.3%
Total of other impurity ≤0.3%

 

Impurity A=0.002%
Total of other impurity= 0.05%

Residual solvent

Ethanol ≤2000pm (loss on drying)

 

500ppm

Microbiological test

 

Total aerobic microbial count: ≤1X10²CFU/g


Total molds and yeast count: 1X10²CFU/g


E.coli: absert(1g)

10CFU/G


10CFU/G


Absent

Assay

97.0%~102.0%

 

100.1%

Conclusion

 

The results conforms with USP31

 

 

 

Use:

 

 

1.A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive.


2.Angiotensin II inhibitor prodrug, antihypertensive.


3.Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

 

 

Description:

 

 

Amlodipine (generic name Amlodipine Besylate) is a class of calcium channel blockers.
Amlodipine functionalizes by the dilation of blood vessels and the improvement of blood flow, which lead to lowered blood pressure. Thereby, it is used to treat high bold pressure (hypertension). Lowering high blood pressure also reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions, and kidney problems. Amlodipine is also used to prevent certain types of chest pains (angina), which may help to increase the ability to exercise and decrease the frequency of angina attacks. Amlodipine can be used to treat coronary artery disease (CAD) including chronic stable angina, vasospastic angina, and angiographically documented CAD.

 

Company Profile Introduction

Handan Zhengle Biological Technology Co., Ltd .who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. Our company is honored as the high-tech enterprise which engaged in researching, developing, manufacturing and exporting research chemicals,advanced pharmaceutical intermediates and Active Pharmaceutical Ingredients (API), include kinds of research chemicals, We have own labs to do research,we provide many kinds of research chemicals. We have established a broad customer base in America, Australia,Russia and other European countries, We have built many long business relationship with our customers. We base our goods with all our power so it will definitely meet and surpass every buyer's highest expectations. We guarantee that after purchasing from us , you will never look anywhere else again!

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  • Since: 2017-03-29
  • Address: Traffic Lane,Congtai District, Handan City,Hebei, China
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