CEVIMELINE, HYDROCHLORIDE SALT NEW
| Price | Get Latest Price |
| Package | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 50000KG/month |
| Update Time: | 2023-08-29 |
Product Details
| Product Name: CEVIMELINE, HYDROCHLORIDE SALT | CAS No.: 107233-08-9 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: 50000KG/month | Release date: 2023/08/29 |
| CAS: | 107233-08-9 |
| MF: | C10H17NOS |
| MW: | 199.31 |
| EINECS: | |
| Product Categories: | Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals |
| Mol File: | 107233-08-9.mol |
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| CEVIMELINE, HYDROCHLORIDE SALT Chemical Properties |
| Melting point | 195-197°C |
| Boiling point | 308.5±42.0 °C(Predicted) |
| density | 1.19 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO |
| pka | 9.51±0.40(Predicted) |
| form | Powder |
| CAS DataBase Reference | 107233-08-9 |
| CEVIMELINE, HYDROCHLORIDE SALT Usage And Synthesis |
| Chemical Properties | Off-White Solid |
| Uses | A muscarinic M1 and M3 receptor agonist. Sialagogue |
| Biological Activity | cevimeline is a muscarinic receptor agonist especially on the m1 and m3 receptors. [1]cevimeline has been approved for use against symptoms of dry mouth by activating the m3 receptors of the parasympathetic nervous system. cevimeline is effective and safe in improving symptoms of dry eye with 20 mg three times per day [2]. cevimeline increased the intracellular ca+ level in parotid gland acinar cells over 1 μm and rat, enhanced the excitability via muscarinic receptors, thereby, cevimeline alleviates dry mouth symptoms by stimulating secretion by the salivary glands. cevimeline has a longer duration of salivation[3]. cevimeline plays a part in alzheimer’s disease. cevimeline decreased aβ (1–40) level in the cerebrospinal fluid (csf) at 1 mg/kg without changing α-apps in rabbit and significantly decreased csf aβ in ad patients.[4] |
| references | 1. f. b. vivino, i. al-hashimi, z. khan, f. g. leveque, p. l. salisbury, 3rd, t. k. tran-johnson, c. c. muscoplat, m. trivedi, b. goldlust and s. c. gallagher, arch intern med 1999, 159, 174-181. 2. m. ono, e. takamura, k. shinozaki, t. tsumura, t. hamano, y. yagi and k. tsubota, am j ophthalmol 2004, 138, 6-17. 3. k. ono, t. inagaki, t. iida, r. hosokawa and k. inenaga, j med invest 2009, 56 suppl, 375. 4. a. fisher, z. pittel, r. haring, n. bar-ner, m. kliger-spatz, n. natan, i. egozi, h. sonego, i. marcovitch and r. brandeis, j mol neurosci 2003, 20, 349-356. |
Packing &shipping&Payment
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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