ISRIB NEW

Supply high Purity ISRIB CAS:548470-11-7

Product Name:ISRIB

Synonyms:ISRIB;N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE);ISRIB N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE);Integrated Stress Response inhibitor;trans-N,N′-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)-acetamide;2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide;N,N'-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide];

2-(4-chlorophenoxy)-N-(4-{[(4-chlorophenoxy)acetyl]amino}cyclohexyl)acetami de

CAS:548470-11-7

MF:C22H24Cl2N2O4

MW:451.34

Melting point:270-273°C

Boiling point:719.0±60.0 °C(Predicted)

density:1.33±0.1 g/cm3(Predicted)

storage temp.:2-8°C

solubility:DMSO: soluble1mg/mL, clear (warmed)

application:ISRIB (integrated stress response inhibitor) has been used as an inhibitor of integrated stress response

Description   

ISRIB (integrated stress response inhibitor) is an experimental drug that reverses the effects of eIF2α phosphorylation with an IC50 of 5 nM. It was discovered in the laboratory of Peter Walter at University of California, San Francisco (UCSF) through a semi-automated screening of a large library of small molecules by Carmela Sidrauski, who decided to pursue research on it. It has been shown to inhibit eIF2α phosphorylation-induced stress granule (SG) formation. Since eIF2α phosphorylation is known to be involved in memory formation, ISRIB was tested to see whether it would be active in vivo, and was found to readily cross the blood-brain barrier, with a half-life of eight hours.