Sulfanilamide

Sulfonamide name

Chinese name sulfanilamide

The English name is sulfanilamide

Chinese nickname for aminobenzene sulfonamide | the azole lu | 4 - aminobenzene sulfonamide | crystalline sulfanilamide

More English nicknames

Sulfonamide bioactivity

Sulfanilamide is a bacterial dihydrosphenic acid synthetase inhibitor with an IC50 of 320 μM.

Related category

Signal path > > Anti-infection > > bacteria

Research Field > > infection

Reference literature

[1]. McCullough, J.L. and T.H. Maren, Inhibition of dihydropteroate synthetase from Escherichia coli by sulfones and sulfonamides. Antimicrob Agents Chemother, 1973. 3(6): p. 665-9.

[2]. Meneau, I., et al., Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae. Antimicrob Agents Chemother, 2004. 48(7): p. 2610-6.

[3]. Hughes, W.T. and J. Killmar, Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother, 1996. 40(4): p. 962-5.

Physical and chemical properties of sulfonamide

Density 1.4± 0.1g /cm3

Boiling point 400.5±47.0 °C at 760 mmHg

Melting point 164-166 °C(lit.)

Molecular formula C6H8N2O2S

Molecular weight 172.205

Flash point 196.0±29.3 °C

Exact mass 172.030655

PSA 94.56000

LogP minus 0.72

Appearance properties white to light yellow crystalline powder

Vapor pressure 0.0±0.9 mmHg at 25°C

Refractive index 1.628

Storage condition

1. In a cool, ventilated and dry place, prevent heat, sun protection and moisture. Store and transport in accordance with general chemical regulations.

2. Use lining plastic bag to cover the sack, or lining plastic bag, middle layer with kraft paper bag, coat fiber cloth bag packaging. Generally each bag 40kg. Store in a cool, ventilated, dry place, heat, sunscreen, moisture-proof. Store and transport in accordance with general chemical regulations.

stability

It can be used as medicine and has an inhibitory effect on the growth and reproduction of bacteria. In large doses, sulfonamide can cause death due to a loss of balance between absorption and excretion. Dog transoral LD50:2000mg/kg. A large amount of sulfanilamide can cause hypoxia, nausea, vomiting, diarrhea and other side effects, affect the liver and kidney, can also cause tinnitus, vertigo, headache, and even a variety of mental symptoms, until death. Operators should wear protective equipment.

Water solubility 7.5g /L at 25 ºC

Molecular structure

1. Molar refractive index: 42.80

2, molar volume (cm3/mol) : 120.6

3. Isotropic specific volume (90.2K) : 340.9

4. Surface tension (dyne/cm) : 63.7

5. Polarization (10-24cm3) : 16.97

Computational chemistry

1. Reference value for calculating hydrophobic parameters (XlogP) : None

2. Number of hydrogen bond donors :2

3. Number of hydrogen bond receptors :4

4. Number of rotatable bonds :1

5. Number of tautomers: None

6. Topological molecular polar surface area 94.6

7. Number of heavy atoms :11

8. Surface charge :0

9. Complexity :211

10. Number of isotope atoms :0

11. Determine the number of primary constitutive centers :0

12. Number of indeterminate atomic orthotropic centers :0

13. Determine the number of chemical bond constitutive centers :0

14. Number of uncertain bond constitutive centers :0

15. Number of covalent bond units :1

more

1. Properties: White granular or powdered crystal, odorless, slightly bitter taste.

2. Density (g/mL,25/4℃) : 1.08

3. Relative vapor density (g/mL, air =1) : uncertain

4. Melting point (ºC) : 165~166

5. Boiling point (ºC, atmospheric pressure) : Uncertain

6. Boiling point (ºC, 5.2kPa) : Uncertain

7. Refractive index: uncertain

8. Flash point (ºC) : Uncertain

9. Specific rotation (º) : Uncertain

10. Spontaneous ignition point or ignition temperature (ºC) : uncertain

11. Vapor pressure (kPa,25ºC) : Uncertain

12. Saturated vapor pressure (kPa,60ºC) : Uncertain

13. Heat of combustion (KJ/mol) : uncertain

14. Critical temperature (ºC) : Uncertain

15. Critical pressure (KPa) : Uncertain

16. The opposite value of the oil-water (octanol/water) partition coefficient: uncertain

17. Upper explosion limit (%,V/V) : Uncertain

18. Lower explosive limit (%,V/V) : Uncertain

19 Solubility: slightly soluble in cold water, ethanol, methanol, ether and acetone, easily soluble in boiling water, glycerin, hydrochloric acid, potassium hydroxide and sodium hydroxide solution, insoluble in chloroform, ether, benzene, petroleum ether.