THIP HYDROCHLORIDE

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THIP HYDROCHLORIDE Basic information

Product Name: THIP HYDROCHLORIDE

Synonyms: THIP HYDROCHLORIDE;4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3(2h)-onehydrate;4-c)pyridin-3(2h)-one,4,5,6,7-tetrahydro-isoxazolo(hydrate;gaboxadol;4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL;4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL HYDROCHLORIDE;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one;THIP

CAS: 64603-91-4

MF: C6H8N2O2

MW: 140.14

EINECS: 264-963-0

Product Categories: GABA/Glycine receptor

Mol File: 64603-91-4.mol

THIP HYDROCHLORIDE Structure

THIP HYDROCHLORIDE Chemical Properties

Melting point 242-244° (dec)

density 1.36±0.1 g/cm3(Predicted)

storage temp. Store at RT

solubility ethanol: 0.91 mg/mL

form solid

pka pKa (water, 25°): 4.44 ±0.03; 8.48 ±0.04

color white

Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

Safety Information

Safety Statements 22-24/25

WGK Germany 3

RTECS NY3396800

MSDS Information

Provider Language

SigmaAldrich English

THIP HYDROCHLORIDE Usage And Synthesis

Description Gaboxadol HCl (64603-91-4) is a GABA-A receptor agonist. Hypnotic agent.

Uses GABAa agonist, GABAc antagonist

Definition ChEBI: 4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3-ol is an oxazole.

Biological Activity Systemically active GABA A receptor agonist and GABA C receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

References 1) Meera et al. (2011), Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors; J. Neurophysiol., 106 2057