Vagistat NEW
| Price | Get Latest Price |
| Package | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 50000KG/month |
| Update Time: | 2023-08-29 |
Product Details
| Product Name: Vagistat | CAS No.: 65899-73-2 |
| EC-No.: 265-973-8 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: 50000KG/month |
| Release date: 2023/08/29 |
| CAS: | 65899-73-2 |
| MF: | C16H13Cl3N2OS |
| MW: | 387.71 |
| EINECS: | 265-973-8 |
| Product Categories: | AGRYLIN;Antifungal;Active Pharmaceutical Ingredients |
| Mol File: | 65899-73-2.mol |
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| Vagistat Chemical Properties |
| Melting point | 79-81oC |
| Boiling point | 534.5±50.0 °C(Predicted) |
| density | 1.3115 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| RTECS | NI4480000 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Very slightly soluble in water, very soluble in methylene chloride, freely soluble in alcohol. |
| pka | 6.66±0.12(Predicted) |
| form | powder |
| color | white to off-white |
| CAS DataBase Reference | 65899-73-2(CAS DataBase Reference) |
| Vagistat Usage And Synthesis |
| Description | Tioconazole is an antifungal agent, closely related to miconazole. Tioconazole is effective in the topical treatment of superficial fungal infections and appears to be more potent than miconazole against Candida and Trichophyton species. |
| Chemical Properties | White powder EINECS: 265-973-8 |
| Originator | Pfizer (United Kiugdom) |
| Uses | antithrombotic |
| Uses | Tioconazole is an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical). |
| Uses | Potent inhibitor of cytochrome-P450 |
| Definition | ChEBI: A member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2. |
| Manufacturing Process | A solution of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (1.5 g, 5.8 mmol) dissolved in dry tetrahydrofuran (10 ml) was added to a stirred suspension of sodium hydride (0.39 g, as 80% dispersion in oil, 16 mmol) in dry tetrahydrofuran (10 ml) and warmed to 70°C for 90 minutes. The mixture was cooled in ice and a solution of 2-chloro-3- chloromethylthiophene (8.8 mmol) in dry tetrahydrofuran was added. The mixture was heated at 70°C for 3 hours and allowed to stir at room temperature overnight. The solvent was removed under vacuum and the residue stirred with dry ether (200 ml). The ether solution was filtered through Celite and saturated with hydrogen chloride gas to precipitate an oil which was solidified by trituration with ether and ethyl acetate. The solid product was collected and recrystallized from a mixture of acetone and diisopropyl ether to give the product, melting point 168°C to 170°C. |
| Brand name | TROSYL |
| Therapeutic Function | Antifungal |
| Clinical Use | 1-[2-[(2-chloro-3-thienyl)methoxy]2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole (Vagistat) is used for the treatment ofvulvovaginal candidiasis. A vaginal ointment containing6.5% of the free base is available. Tioconazole is more effectiveagainst Torulopsis glabrata than are other azoles. |
Product picture
Packing &shipping&Payment
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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China- Since: 2017-12-08
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