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Postion:Product Catalog >API>Vitamins and Minerals medicines>Vitamins AD drugs>Vitamin A palmitate
Vitamin A palmitate
  • Vitamin A palmitate
  • Vitamin A palmitate

Vitamin A palmitate NEW

Price $5 $0.1
Package 1KG 1000KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-27

Product Details

Product Name: Vitamin A palmitate CAS No.: 79-81-2
Min. Order: 1KG Purity: 98%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/27
Lead time: In stock, ready for shipment Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Name: Tina

 1. Materials information


Names

Nameall-trans-retinyl palmitate
SynonymMore Synonyms

 Retinyl palmitate Biological Activity

DescriptionRetinyl palmitate is an ester of Retinol and is the major form of vitamin A found in the epidermis. Retinyl palmitate has been widely used in pharmaceutical and cosmetic formulations.
Related Catalog
Natural Products >> Others
Research Areas >> Others
Target

Human Endogenous Metabolite

In VitroRetinyl palmitate has a high molecular weight and a stable formulation. To be active, Retinyl palmitate should be enzymatically converted in the skin to retinol by cleavage of the ester linkage and must then be converted to tretinoin via oxidative processes[1].
In VivoThe topical administration of Retinyl palmitate in rats results in increased protein and collagen and an epidermal thickening[1].
References

[1]. Oliveira MB, et al. Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging. Biomed Res Int. 2014;2014:632570.

 Chemical & Physical Properties

Density0.9±0.1 g/cm3
Boiling Point607.5±24.0 °C at 760 mmHg
Melting Point41678ºC
Molecular FormulaC36H60O2
Molecular Weight524.860
Flash Point79.7±21.2 °C
Exact Mass524.459351
PSA26.30000
LogP14.83
Appearance of Charactersoil
Vapour Pressure0.0±1.7 mmHg at 25°C
Index of Refraction1.508
Storage condition2-8°C

 MSDS

Retinyl palmitate MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • VH6860000

  • CHEMICAL NAME :

  • Retinol, all-trans-, palmitate

  • CAS REGISTRY NUMBER :

  • 79-81-2

  • BEILSTEIN REFERENCE NO. :

  • 1917366

  • LAST UPDATED :

  • 199701

  • DATA ITEMS CITED :

  • 38

  • MOLECULAR FORMULA :

  • C36-H60-O2

  • MOLECULAR WEIGHT :

  • 524.96

  • WISWESSER LINE NOTATION :

  • L6UTJ A1 B1U1Y1&U2U1Y1&U2OV15 C1 C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 7910 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 6060 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 4760 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 5250 ku/kg/21D-I

  • TOXIC EFFECTS :

  • Liver - other changes Musculoskeletal - other changes Related to Chronic Data - death

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 13750 ug/kg

  • SEX/DURATION :

  • female 35 week(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 36 mg/kg

  • SEX/DURATION :

  • male 26 day(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Paternal Effects - testes, epididymis, sperm duct

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 248 mg/kg

  • SEX/DURATION :

  • female 8 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - Central Nervous System

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 16500 ug/kg

  • SEX/DURATION :

  • female 8-10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - behavioral

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 206 mg/kg

  • SEX/DURATION :

  • female 8 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 275 mg/kg

  • SEX/DURATION :

  • female 8 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 440 mg/kg

  • SEX/DURATION :

  • female 9 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 138 mg/kg

  • SEX/DURATION :

  • female 16 day(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Maternal Effects - uterus, cervix, vagina

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 275 mg/kg

  • SEX/DURATION :

  • female 11 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - fetal death

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 82500 ug/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - musculoskeletal system

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 413 mg/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 1350 mg/kg

  • SEX/DURATION :

  • female 11-15 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - behavioral

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 275 mg/kg

  • SEX/DURATION :

  • female 7 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 275 mg/kg

  • SEX/DURATION :

  • female 8 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 275 mg/kg

  • SEX/DURATION :

  • female 12 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - musculoskeletal system

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Unreported

  • DOSE :

  • 660 mg/kg

  • SEX/DURATION :

  • female 8-10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - behavioral

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 262 mg/kg

  • SEX/DURATION :

  • female 11 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 1321 mg/kg

  • SEX/DURATION :

  • female 8-13 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Specific Developmental Abnormalities - urogenital system

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 660 mg/kg

  • SEX/DURATION :

  • female 9 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - skin and skin appendages

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 220 mg/kg

  • SEX/DURATION :

  • female 8 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 330 mg/kg

  • SEX/DURATION :

  • female 8 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - fetal death

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 28 mg/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - musculoskeletal system

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 220 mg/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 330 mg/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 28 mg/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - fetal death

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 110 mg/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - musculoskeletal system

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 2750 ug/kg

  • SEX/DURATION :

  • female 9 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 2750 ug/kg

  • SEX/DURATION :

  • female 13 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

  • TYPE OF TEST :

  • Sister chromatid exchange

  • TEST SYSTEM :

  • Human Fibroblast

  • DOSE/DURATION :

  • 27500 ug/L

  • REFERENCE :

  • MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,317,1978 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(3),279,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80573 No. of Facilities: 221 (estimated) No. of Industries: 4 No. of Occupations: 10 No. of Employees: 9773 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80573 No. of Facilities: 893 (estimated) No. of Industries: 8 No. of Occupations: 23 No. of Employees: 18737 (estimated) No. of Female Employees: 8842 (estimated)

 Safety Information

SymbolArticle illustration Article illustration
GHS02, GHS07
Signal WordDanger
Hazard StatementsH225-H319
Precautionary StatementsP210-P280-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective EquipmentEyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard CodesXn:Harmful
Risk PhrasesR63
Safety PhrasesS53-S23-S36/37/39-S45-S36/37
RIDADRUN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany3
RTECSVH6860000
HS Code2936210000

 Synthetic Route

Previous 1/2 Next
Article illustration

Methyl palmitate

CAS#:112-39-0

Article illustration

Retinyl acetate

CAS#:127-47-9

~93%

Article illustration

Retinyl palmitate

CAS#:79-81-2

Literature: DSM IP ASSETS B.V.; BONRATH, Werner; GAA, Alex; STRITT, Claude Patent: WO2014/23772 A1, 2014 ; Location in patent: Page/Page column 9 ;
Article illustration

Retinyl acetate

CAS#:127-47-9

Article illustration

Palmitic acid

CAS#:57-10-3

~78%

Article illustration

Retinyl palmitate

CAS#:79-81-2

Article illustration

Vitamin A

CAS#:68-26-8

Literature: Eastman Chemical Company Patent: US7566795 B2, 2009 ; Location in patent: Page/Page column 11 ;
Article illustration

Retinyl acetate

CAS#:127-47-9

Article illustration

Palmitic acid

CAS#:57-10-3

~73%

Article illustration

Retinyl palmitate

CAS#:79-81-2

Literature: Zhu, Kai; Wang, Jianqiang; Wang, Yan-Hua; Liu, Hui; Han, Ping-Fang; Wei, Ping Journal of Nanoscience and Nanotechnology, 2011 , vol. 11, # 9 p. 7593 - 7602

 Precursor & DownStream

Precursor  6

Previous 1/2 Next

  • Article illustration CAS#:112-39-0
    Methyl palmitate

  • Article illustration CAS#:127-47-9
    Retinyl acetate

  • Article illustration CAS#:57-10-3
    Palmitic acid

  • Article illustration CAS#:110-86-1
    Pyridine

DownStream  2


  • Article illustration CAS#:4759-48-2
    Isotretinoin

  • Article illustration CAS#:302-79-4
    Retinoic acid

 Customs

HS Code2936210000



2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621










Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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Henan Fengda Chemical Co., Ltd

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  • Since: 2023-02-10
  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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