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Domperidone(57808-66-9)

Domperidone(57808-66-9)
Product IdentificationBack to Contents
【Product Name】

Domperidone
【Synonyms】

4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine
5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
KW-5338
Motilium
Peridon
【CAS】

57808-66-9
【Formula】

C22H24ClN5O2
【Molecular Weight】

425.92
【EINECS】

260-968-7
【RTECS】

DE2275900
【RTECS Class】

Drug; Reproductive Effector; Human Data
【Merck】

12,3476
【Beilstein/Gmelin】

903774
【Beilstein Reference】

5-24-02-00402
Physical and Chemical PropertiesBack to Contents
【Appearance】

White powder.
【Solubility in water】

Insoluble
【Melting Point】

236 - 239
【pKa/pKb】

4.80 (pKb)
【Usage】

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.
First Aid MeasuresBack to Contents
【Ingestion】

If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
【Inhalation】

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
【Skin】

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
【Eyes】

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
Handling and StorageBack to Contents
【Storage】

Keep tightly closed.
Hazards IdentificationBack to Contents
【Inhalation】

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
【Skin】

May cause skin irritation. May be harmful if absorbed through the skin.
【Eyes】

May cause eye irritation.
【Ingestion】

May be harmful if swallowed.
【Hazards】

Emits toxic fumes under fire conditions.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Compatible chemical-resistant gloves.
【Respirators】

Government approved respirator.
【Exposure Effects】

Harmful. Possible risk of harm to the unborn child. Possible risk of impaired fertility. Target organ(s): G.I. System.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability and ReactivityBack to Contents
【Stability】

Stable at normal temperatures and pressures.
【Incompatibilities】

Strong oxidizing agents.
【Decomposition】

Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.
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