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ChemicalBook >> CAS DataBase List >> N-[4-[(2-Amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

N-[4-[(2-Amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

N-[4-[(2-Amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide price.
  • $28 - $2300
  • Product name: N-[4-[(2-Amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
  • CAS: 1025720-94-8
  • MF: C25H19ClF2N4O4
  • MW: 512.89
  • EINECS:
  • MDL Number:MFCD16495773
  • Synonyms:N-[4-[(2-Amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide;N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide;N-[4-[(2-Amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide BMS 777607;BMS777607 (ASLAN-002);ASLAN-002;N-(4-((2-Amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2;CS-1911;N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxyphenyl(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide
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  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
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  • 1unit
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  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberX7495
  • Product descriptionN-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5703
  • Product descriptionBMS-777607
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA5703
  • Product descriptionBMS-777607
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5703
  • Product descriptionBMS-777607
  • Packaging10mM(in 1mL DMSO)
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5703
  • Product descriptionBMS-777607
  • Packaging25mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5703
  • Product descriptionBMS-777607
  • Packaging100mg
  • Price$680
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60249
  • Product descriptionBMS-777607 ≥98%
  • Packaging10mg
  • Price$308
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFB64961
  • Product descriptionBMS 777607
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
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  • ManufacturerCayman Chemical
  • Product number18517
  • Product descriptionBMS-777607 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number18517
  • Product descriptionBMS-777607 ≥98%
  • Packaging5mg
  • Price$142
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18517
  • Product descriptionBMS-777607 ≥98%
  • Packaging10mg
  • Price$249
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18517
  • Product descriptionBMS-777607 ≥98%
  • Packaging50mg
  • Price$793
  • Updated2024-03-01
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  • ManufacturerChemScene
  • Product numberCS-0227
  • Product descriptionBMS777607 99.48%
  • Packaging5mg
  • Price$84
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-0227
  • Product descriptionBMS777607 99.48%
  • Packaging10mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0227
  • Product descriptionBMS777607 99.48%
  • Packaging50mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0227
  • Product descriptionBMS777607 99.48%
  • Packaging100mg
  • Price$744
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7495 N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 10mg $218 2021-12-16 Buy
ApexBio Technology A5703 BMS-777607 1unit $28 2021-12-16 Buy
ApexBio Technology A5703 BMS-777607 5mg $80 2021-12-16 Buy
ApexBio Technology A5703 BMS-777607 10mM(in 1mL DMSO) $85 2021-12-16 Buy
ApexBio Technology A5703 BMS-777607 25mg $250 2021-12-16 Buy
ApexBio Technology A5703 BMS-777607 100mg $680 2021-12-16 Buy
Arctom CFN60249 BMS-777607 ≥98% 10mg $308 2021-12-16 Buy
Biosynth Carbosynth FB64961 BMS 777607 10mg $125 2021-12-16 Buy
Cayman Chemical 18517 BMS-777607 ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 18517 BMS-777607 ≥98% 5mg $142 2024-03-01 Buy
Cayman Chemical 18517 BMS-777607 ≥98% 10mg $249 2024-03-01 Buy
Cayman Chemical 18517 BMS-777607 ≥98% 50mg $793 2024-03-01 Buy
ChemScene CS-0227 BMS777607 99.48% 5mg $84 2021-12-16 Buy
ChemScene CS-0227 BMS777607 99.48% 10mg $144 2021-12-16 Buy
ChemScene CS-0227 BMS777607 99.48% 50mg $420 2021-12-16 Buy
ChemScene CS-0227 BMS777607 99.48% 100mg $744 2021-12-16 Buy

Properties

Boiling point :667.9±55.0 °C(Predicted)
Density :1.49
storage temp. :Store at -20°C
solubility :≥25.65 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :10.54±0.70(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively. At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50s = 14, 16, 78, 120, and 180 nM, respectively). In cancer cells, BMS-777607 induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis. In tumor xenograft models, BMS-777607 at 50 mg/kg/mouse inhibits the growth of tumor cells expressing Met/Ron.