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ChemicalBook >> CAS DataBase List >> 1-(4-METHOXYBENZYL)-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXYLIC ACID

1-(4-METHOXYBENZYL)-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXYLIC ACID

1-(4-METHOXYBENZYL)-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXYLIC ACID price.
  • $45 - $5120
  • Product name: 1-(4-METHOXYBENZYL)-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXYLIC ACID
  • CAS: 338747-41-4
  • MF: C18H15NO4
  • MW: 309.32
  • EINECS:
  • MDL Number:MFCD01315710
  • Synonyms:1-(4-METHOXYBENZYL)-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXYLIC ACID;1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;Benzyl quinolone carboxylic acid;BQCA;3-Quinolinecarboxylic acid, 1,4-dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-;1-(4-Methoxybenzyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic ...;mAChR,Muscarinic acetylcholine receptor,Inhibitor,inhibit,BQCA
30 prices
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Brand
  • AccelPharmtech
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 50
  • 1G
  • 5G
  • 25G
  • ManufacturerAccelPharmtech
  • Product numberC1630
  • Product description1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 97.00%
  • Packaging1G
  • Price$2370
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberC1630
  • Product description1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 97.00%
  • Packaging5G
  • Price$2750
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberC1630
  • Product description1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 97.00%
  • Packaging25G
  • Price$5120
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3996AB
  • Product description1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid
  • Packaging5mg
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3996AB
  • Product description1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid
  • Packaging10mg
  • Price$153
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0155574
  • Product description1-(4-METHOXYBENZYL)-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXYLIC ACID 95.00%
  • Packaging5G
  • Price$4966.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3869
  • Product descriptionBQCA
  • Packaging5mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3869
  • Product descriptionBQCA
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3869
  • Product descriptionBQCA
  • Packaging25mg
  • Price$152
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3869
  • Product descriptionBQCA
  • Packaging50mg
  • Price$276
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15393
  • Product descriptionBQCA ≥98%
  • Packaging5mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15393
  • Product descriptionBQCA ≥98%
  • Packaging10mg
  • Price$96
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15393
  • Product descriptionBQCA ≥98%
  • Packaging25mg
  • Price$225
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15393
  • Product descriptionBQCA ≥98%
  • Packaging50mg
  • Price$419
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM252313
  • Product descriptionBQCA 95%
  • Packaging100mg
  • Price$467
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6880
  • Product descriptionBQCA 98.59%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech C1630 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 97.00% 1G $2370 2021-12-16 Buy
AccelPharmtech C1630 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 97.00% 5G $2750 2021-12-16 Buy
AccelPharmtech C1630 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 97.00% 25G $5120 2021-12-16 Buy
AK Scientific 3996AB 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 5mg $119 2021-12-16 Buy
AK Scientific 3996AB 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 10mg $153 2021-12-16 Buy
American Custom Chemicals Corporation CHM0155574 1-(4-METHOXYBENZYL)-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXYLIC ACID 95.00% 5G $4966.5 2021-12-16 Buy
ApexBio Technology C3869 BQCA 5mg $53 2021-12-16 Buy
ApexBio Technology C3869 BQCA 10mg $70 2021-12-16 Buy
ApexBio Technology C3869 BQCA 25mg $152 2021-12-16 Buy
ApexBio Technology C3869 BQCA 50mg $276 2021-12-16 Buy
Cayman Chemical 15393 BQCA ≥98% 5mg $62 2024-03-01 Buy
Cayman Chemical 15393 BQCA ≥98% 10mg $96 2024-03-01 Buy
Cayman Chemical 15393 BQCA ≥98% 25mg $225 2024-03-01 Buy
Cayman Chemical 15393 BQCA ≥98% 50mg $419 2024-03-01 Buy
Chemenu CM252313 BQCA 95% 100mg $467 2021-12-16 Buy
ChemScene CS-6880 BQCA 98.59% 5mg $50 2021-12-16 Buy

Properties

Melting point :210-212 °C
Boiling point :492.6±45.0 °C(Predicted)
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL (clear solution)
form :powder
pka :0.70±0.20(Predicted)
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR), as it dose-dependently reduces the concentration of acetylcholine required to activate the M1 receptor. The effective range for potentiation of M1 in cells by BQCA is 0.1 to 100 μM with an inflection point value of 845 nM when 3 nM acetylcholine is used. BQCA displays no potentiation, agonism, or antagonism at other mAChRs at concentrations up to 100 μM. It has excellent brain penetration and increases the firing rate of medial prefrontal cortex neurons in vivo in rats. BQCA prevents scopolamine-induced memory deficits in both contextual fear conditioning and a spontaneous alternation task in mice. It also restores impairment in reversal learning in a mouse model of Alzheimer’s disease and improves memory performance in rats.

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