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ChemicalBook >> CAS DataBase List >> AVL-292

AVL-292

AVL-292 price.
  • $44 - $1949.9
  • Product name: AVL-292
  • CAS: 1202757-89-8
  • MF: C22H22FN5O3
  • MW: 423.44
  • EINECS:
  • MDL Number:MFCD25976876
  • Synonyms:AVL-292;LMK-435;N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide;2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-;CC-292 (AVL-292);CC-292,LMK-435;N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide AVL292;CC-292
23 prices
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Brand
  • AK Scientific
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5mg
  • 10mM(in 1mL DMSO)
  • 2x5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2235AH
  • Product descriptionN-[3-[[5-Fluoro-2-[4-(2-methoxyethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
  • Packaging5mg
  • Price$142
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3206
  • Product descriptionAVL-292
  • Packaging10mM(in 1mL DMSO)
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3206
  • Product descriptionAVL-292
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3206
  • Product descriptionAVL-292
  • Packaging50mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2226
  • Product descriptionAVL292-CC292 98%
  • Packaging2x5mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146216
  • Product descriptionAVL-292 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146216
  • Product descriptionAVL-292 >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146216
  • Product descriptionAVL-292 >98%
  • Packaging1g
  • Price$1949.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC64970
  • Product descriptionCC 292
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC64970
  • Product descriptionCC 292
  • Packaging50mg
  • Price$263
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17993
  • Product descriptionAVL-292 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17993
  • Product descriptionAVL-292 ≥98%
  • Packaging5mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17993
  • Product descriptionAVL-292 ≥98%
  • Packaging10mg
  • Price$341
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17993
  • Product descriptionAVL-292 ≥98%
  • Packaging50mg
  • Price$957
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM167684
  • Product descriptionN-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
  • Packaging100mg
  • Price$377
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1482
  • Product descriptionSpebrutinib 99.69%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2235AH N-[3-[[5-Fluoro-2-[4-(2-methoxyethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide 5mg $142 2021-12-16 Buy
ApexBio Technology A3206 AVL-292 10mM(in 1mL DMSO) $88 2021-12-16 Buy
ApexBio Technology A3206 AVL-292 10mg $120 2021-12-16 Buy
ApexBio Technology A3206 AVL-292 50mg $350 2021-12-16 Buy
Axon Medchem Axon2226 AVL292-CC292 98% 2x5mg $198 2021-12-16 Buy
Biorbyt Ltd orb146216 AVL-292 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb146216 AVL-292 >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb146216 AVL-292 >98% 1g $1949.9 2021-12-16 Buy
Biosynth Carbosynth FC64970 CC 292 10mg $75 2021-12-16 Buy
Biosynth Carbosynth FC64970 CC 292 50mg $263 2021-12-16 Buy
Cayman Chemical 17993 AVL-292 ≥98% 1mg $44 2024-03-01 Buy
Cayman Chemical 17993 AVL-292 ≥98% 5mg $193 2024-03-01 Buy
Cayman Chemical 17993 AVL-292 ≥98% 10mg $341 2024-03-01 Buy
Cayman Chemical 17993 AVL-292 ≥98% 50mg $957 2024-03-01 Buy
Chemenu CM167684 N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 98% 100mg $377 2021-12-16 Buy
ChemScene CS-1482 Spebrutinib 99.69% 5mg $60 2021-12-16 Buy

Properties

Density :1.322±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :13.22±0.70(Predicted)
CAS DataBase Reference :1202757-89-8

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Description

Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).

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