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ChemicalBook >> CAS DataBase List >> Crizotinib

Crizotinib

Crizotinib price.
  • $5 - $1963.5
  • Product name: Crizotinib
  • CAS: 877399-52-5
  • MF: C21H22Cl2FN5O
  • MW: 450.34
  • EINECS:638-814-9
  • MDL Number:MFCD12407409
  • Synonyms:(R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylaMine;[3-[[(R)-1-(2,6-Dichloro-3- fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]aMine;2-PyridinaMine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-;Crozotinib;Crizotinib,PF-02341066;Crizotinib (PF2341066);PF-02341066 Crizotinib;3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
Price53 Properties Safety Information Description
53 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
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  • 10mM(in 1mL DMSO)
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-C0699-M050
  • Product descriptionCrizotinib ≥98%(HPLC)
  • Packaging50mg
  • Price$282
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberW9013
  • Product descriptionCrizotinib
  • Packaging250mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106537
  • Product description(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+%
  • Packaging5mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106537
  • Product description(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+%
  • Packaging10mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106537
  • Product description(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+%
  • Packaging25mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106537
  • Product description(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+%
  • Packaging50mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106537
  • Product description(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+%
  • Packaging100mg
  • Price$14
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106537
  • Product description(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+%
  • Packaging250mg
  • Price$22
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106537
  • Product description(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+%
  • Packaging1g
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106537
  • Product description(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+%
  • Packaging5g
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028584
  • Product descriptionCRIZOTINIB 95.00%
  • Packaging5MG
  • Price$430
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028584
  • Product descriptionCRIZOTINIB 95.00%
  • Packaging10MG
  • Price$750.75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028584
  • Product descriptionCRIZOTINIB 95.00%
  • Packaging100MG
  • Price$1963.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8802
  • Product description(S)-Crizotinib
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3020
  • Product description(R)-Crizotinib
  • Packaging10mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8802
  • Product description(S)-Crizotinib
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-C0699-M050 Crizotinib ≥98%(HPLC) 50mg $282 2021-12-16 Buy
AK Scientific W9013 Crizotinib 250mg $150 2021-12-16 Buy
Ambeed A106537 (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+% 5mg $5 2021-12-16 Buy
Ambeed A106537 (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+% 10mg $6 2021-12-16 Buy
Ambeed A106537 (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+% 25mg $8 2021-12-16 Buy
Ambeed A106537 (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+% 50mg $10 2021-12-16 Buy
Ambeed A106537 (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+% 100mg $14 2021-12-16 Buy
Ambeed A106537 (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+% 250mg $22 2021-12-16 Buy
Ambeed A106537 (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+% 1g $50 2021-12-16 Buy
Ambeed A106537 (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine 98+% 5g $168 2021-12-16 Buy
American Custom Chemicals Corporation API0028584 CRIZOTINIB 95.00% 5MG $430 2021-12-16 Buy
American Custom Chemicals Corporation API0028584 CRIZOTINIB 95.00% 10MG $750.75 2021-12-16 Buy
American Custom Chemicals Corporation API0028584 CRIZOTINIB 95.00% 100MG $1963.5 2021-12-16 Buy
ApexBio Technology A8802 (S)-Crizotinib 1unit $28 2021-12-16 Buy
ApexBio Technology A3020 (R)-Crizotinib 10mg $50 2021-12-16 Buy
ApexBio Technology A8802 (S)-Crizotinib 5mg $75 2021-12-16 Buy
Next Last

Properties

Melting point :192 °C
Boiling point :599.2±50.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming)
pka :9.81±0.10(Predicted)
form :powder
color :white to tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChIKey :KTEIFNKAUNYNJU-GFCCVEGCSA-N
SMILES :C1(N)=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@@H](C1=C(Cl)C=CC(F)=C1Cl)C
CAS DataBase Reference :877399-52-5

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. In August 2011, the United States FDA approved crizotinib for the treatment of anaplastic lymphoma kinase (ALK) rearranged non-small-cell lung cancer (NSCLC).

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Suppliers and manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.
Crizotinib
$0.00 /25kg
Crizotinib CAS:877399-52-5
Jinan Million Pharmaceutical Co., Ltd
Crizotinib
$0.50 /2kg
Crizotinib CAS:877399-52-5
Henan Fengda Chemical Co., Ltd
Crizotinib
$0.10 /1000KG
Crizotinib CAS:877399-52-5
Wuhan Golt Biotech Co., Ltd.
Zhengzhou Anhuida Chemical Co., Ltd
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
Capot Chemical Co.,Ltd.
Nanjing Gold Pharmaceutical Technology Co. Ltd.
Shanghai Bojing Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.