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ChemicalBook >> CAS DataBase List >> Stattic

Stattic

Stattic price.
  • $35 - $2200
  • Product name: Stattic
  • CAS: 19983-44-9
  • MF: C8H5NO4S
  • MW: 211.19
  • EINECS:
  • MDL Number:MFCD00173799
  • Synonyms:BUTTPARK 97\04-73;6-NITRO-1H-1LAMBDA6-BENZO[B]THIOPHENE-1,1-DIONE;AKOS 1001;6-Nitro-1-benzothiophene 1,1-dioxide;1,1-DIOXO-6-NITROBENZO(B)THIOPHENE;6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound;Stattic;6-Nitrobenzo[b]thiophene1,1-dioxide
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  • Acints
  • Advanced Chemicals Intermediatesced Chemicals Intermediates
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
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  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
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  • 1g
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  • 10mM(in 1mL DMSO)
  • ManufacturerAcints
  • Product numberACI-03835
  • Product description6-Nitro-benzo[b]thiophene1,1-dioxide 95%+
  • Packaging1g
  • Price$143.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAcints
  • Product numberACI-03835
  • Product description6-Nitro-benzo[b]thiophene1,1-dioxide 95%+
  • Packaging5g
  • Price$651.05
  • Updated2021-12-16
  • Buy
  • ManufacturerAdvanced Chemicals Intermediatesced Chemicals Intermediates
  • Product numberACI-03835
  • Product description6-Nitro-benzo[b]thiophene1,1-dioxide 95%+
  • Packaging1g
  • Price$143.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2729AH
  • Product descriptionStattic
  • Packaging1g
  • Price$541
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109795
  • Product description6-Nitrobenzo[b]thiophene1,1-dioxide 98%
  • Packaging10mg
  • Price$35
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA109795
  • Product description6-Nitrobenzo[b]thiophene1,1-dioxide 98%
  • Packaging25mg
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109795
  • Product description6-Nitrobenzo[b]thiophene1,1-dioxide 98%
  • Packaging50mg
  • Price$79
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109795
  • Product description6-Nitrobenzo[b]thiophene1,1-dioxide 98%
  • Packaging100mg
  • Price$118
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109795
  • Product description6-Nitrobenzo[b]thiophene1,1-dioxide 98%
  • Packaging250mg
  • Price$178
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA109795
  • Product description6-Nitrobenzo[b]thiophene1,1-dioxide 98%
  • Packaging1g
  • Price$446
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA2224
  • Product descriptionStattic
  • Packaging100mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2224
  • Product descriptionStattic
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2224
  • Product descriptionStattic
  • Packaging25mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS434424
  • Product description6-Nitrobenzo[b]thiophene1,1-dioxide 98%
  • Packaging10mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS434424
  • Product description6-Nitrobenzo[b]thiophene1,1-dioxide 98%
  • Packaging25mg
  • Price$51
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS434424
  • Product description6-Nitrobenzo[b]thiophene1,1-dioxide 98%
  • Packaging50mg
  • Price$78
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Acints ACI-03835 6-Nitro-benzo[b]thiophene1,1-dioxide 95%+ 1g $143.55 2021-12-16 Buy
Acints ACI-03835 6-Nitro-benzo[b]thiophene1,1-dioxide 95%+ 5g $651.05 2021-12-16 Buy
Advanced Chemicals Intermediatesced Chemicals Intermediates ACI-03835 6-Nitro-benzo[b]thiophene1,1-dioxide 95%+ 1g $143.55 2021-12-16 Buy
AK Scientific 2729AH Stattic 1g $541 2021-12-16 Buy
Ambeed A109795 6-Nitrobenzo[b]thiophene1,1-dioxide 98% 10mg $35 2021-12-16 Buy
Ambeed A109795 6-Nitrobenzo[b]thiophene1,1-dioxide 98% 25mg $52 2021-12-16 Buy
Ambeed A109795 6-Nitrobenzo[b]thiophene1,1-dioxide 98% 50mg $79 2021-12-16 Buy
Ambeed A109795 6-Nitrobenzo[b]thiophene1,1-dioxide 98% 100mg $118 2021-12-16 Buy
Ambeed A109795 6-Nitrobenzo[b]thiophene1,1-dioxide 98% 250mg $178 2021-12-16 Buy
Ambeed A109795 6-Nitrobenzo[b]thiophene1,1-dioxide 98% 1g $446 2021-12-16 Buy
ApexBio Technology A2224 Stattic 100mg $200 2021-12-16 Buy
ApexBio Technology A2224 Stattic 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A2224 Stattic 25mg $80 2021-12-16 Buy
Arctom AS434424 6-Nitrobenzo[b]thiophene1,1-dioxide 98% 10mg $35 2021-12-16 Buy
Arctom AS434424 6-Nitrobenzo[b]thiophene1,1-dioxide 98% 25mg $51 2021-12-16 Buy
Arctom AS434424 6-Nitrobenzo[b]thiophene1,1-dioxide 98% 50mg $78 2021-12-16 Buy

Properties

Melting point :187-188 °C
Boiling point :461.1±45.0 °C(Predicted)
Density :1.621±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >20mg/mL
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities. Stattic is a small molecule inhibitor of STAT3. It selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC50 = 5.1 μM at 37°C). At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.

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