WP1130
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- $28 - $2839
- Product name: WP1130
- CAS: 856243-80-6
- MF: C19H18BrN3O
- MW: 384.27
- EINECS:604-604-1
- MDL Number:MFCD18839228
- Synonyms:WP1130;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide;Degrasyn;Degrasyn (WP1130);WP1130 ( Degrasyn );(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide Degrasyn (WP1130);Degrasyn, >=98%
39 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 2mg
- 2x5mg
- 100mg
- 250mg
- 1g
- 1000mg
- 1unit
- 5mg
- 10mg
- 25mg
- 50mg
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberX7509
- Product description(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
- Packaging5mg
- Price$174
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7509
- Product description(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
- Packaging10mg
- Price$233
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7509
- Product description(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
- Packaging25mg
- Price$415
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7509
- Product description(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
- Packaging50mg
- Price$694
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000970
- Product description(2E)-3-(6-BROMO-2-PYRIDINYL)-2-CYANO-N-[(1S)-1-PHENYLBUTYL]-2-PROPENAMIDE 99.00%
- Packaging5MG
- Price$257.4
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8323
- Product descriptionWP1130
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8323
- Product descriptionWP1130
- Packaging5mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8323
- Product descriptionWP1130
- Packaging10mM(in 1mL DMSO)
- Price$76
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8323
- Product descriptionWP1130
- Packaging10mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8323
- Product descriptionWP1130
- Packaging50mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8323
- Product descriptionWP1130
- Packaging100mg
- Price$808
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60378
- Product descriptionDegrasyn(WP1130)
- Packaging10mg
- Price$238
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1779
- Product descriptionWP1130-Degrasyn 99%
- Packaging2x5mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181375
- Product descriptionWP1130 >98%
- Packaging100mg
- Price$838.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181375
- Product descriptionWP1130 >98%
- Packaging250mg
- Price$1504.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181375
- Product descriptionWP1130 >98%
- Packaging1000mg
- Price$2839
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7509 | (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide | 5mg | $174 | 2021-12-16 | Buy |
| AK Scientific | X7509 | (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide | 10mg | $233 | 2021-12-16 | Buy |
| AK Scientific | X7509 | (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide | 25mg | $415 | 2021-12-16 | Buy |
| AK Scientific | X7509 | (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide | 50mg | $694 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000970 | (2E)-3-(6-BROMO-2-PYRIDINYL)-2-CYANO-N-[(1S)-1-PHENYLBUTYL]-2-PROPENAMIDE 99.00% | 5MG | $257.4 | 2021-12-16 | Buy |
| ApexBio Technology | A8323 | WP1130 | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A8323 | WP1130 | 5mg | $65 | 2021-12-16 | Buy |
| ApexBio Technology | A8323 | WP1130 | 10mM(in 1mL DMSO) | $76 | 2021-12-16 | Buy |
| ApexBio Technology | A8323 | WP1130 | 10mg | $119 | 2021-12-16 | Buy |
| ApexBio Technology | A8323 | WP1130 | 50mg | $470 | 2021-12-16 | Buy |
| ApexBio Technology | A8323 | WP1130 | 100mg | $808 | 2021-12-16 | Buy |
| Arctom | CFN60378 | Degrasyn(WP1130) | 10mg | $238 | 2021-12-16 | Buy |
| Axon Medchem | Axon1779 | WP1130-Degrasyn 99% | 2x5mg | $154 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181375 | WP1130 >98% | 100mg | $838.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181375 | WP1130 >98% | 250mg | $1504.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181375 | WP1130 >98% | 1000mg | $2839 | 2021-12-16 | Buy |
Properties
Density :1.358
storage temp. :-20°
solubility :Soluble in DMSO (up to 45 mg/ml), or in Ethanol (up to 25 mg/ml).
form :solid
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
storage temp. :-20°
solubility :Soluble in DMSO (up to 45 mg/ml), or in Ethanol (up to 25 mg/ml).
form :solid
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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Description
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into two subgroups: ubiquitin-specific proteases (USPs) and ubiquitin-specific COOH-terminal hydrolases (UCHs). Recent evidence suggests that several DUBs are activated in tumor cells and many contribute to a transformed phenotype. WP1130 is a second-generation tyrphostin derivative that inhibits the deubiquitinase activity of USP9x, USP5, USP14, and UCH37. At 5 μM, WP1130-mediated inhibition of tumor-activated DUBs induces a rapid accumulation of protein-ubiquitin conjugates, resulting in the formation of aggresomes and apoptosis in a variety of tumor cells. Through this mechanism, WP1130 has been shown to downregulate the antiapoptotic proteins Bcr/Abl and Jak2 and to upregulate the proapoptotic proteins MCL-1 and p53.Related product price
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