1-(2-CHLOROETHOXY)-4-FLUOROBENZENE(WXC08215) synthesis

Yield:64010-10-2 68%

Reaction Conditions:

Stage #1: 4-Fluorophenolwith potassium carbonate in butanone; for 0.5 h;Reflux;
Stage #2: 1-Bromo-2-chloroethane in butanone; for 10 h;Reflux;

Steps:

6.1.1. General procedure for the synthesis of compounds 6c-f

General procedure: A mixture of substituted phenol (10 mmol) and potassium carbonate (15 mmol) in butan-2-one (25 mL) was refluxed for 0.5 h. Then, 1-bromo-2-chloroethane (30 mmol) was added to the reaction mixture and refluxing was continued for 10 h. After completion of the reaction, water (40 mL) was added and the mixture was extracted with diethyl ether several times. The organic phase was washed (10% NaOH solution and water, respectively) and dried (Na₂SO₄). The solvent and the excess of 1-bromo-2-chloroethane were evaporated under reduced pressure to give compounds 6c-f as oil.

References:

Babazadeh-Qazijahani, Mojtaba;Badali, Hamid;Irannejad, Hamid;Afsarian, Mohammad Hosein;Emami, Saeed [European Journal of Medicinal Chemistry,2014,vol. 76,p. 264 - 273]