1-(3-Bromopropyl)-3-chlorobenzene synthesis
- Product Name:1-(3-Bromopropyl)-3-chlorobenzene
- CAS Number:91085-89-1
- Molecular formula:C9H10BrCl
- Molecular Weight:233.53
22991-03-3
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$45.00/50mg
106-95-6
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530-62-1
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$6.00/25g
91085-89-1
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$110.00/100mg
Yield:91085-89-1 85%
Reaction Conditions:
in ethyl acetate;acetonitrile;
Steps:
N.1.B Step B
Step B Bromination A solution of 3-(3-chloro-phenyl)-propan-1-ol (12.54 g, 73.6 mmol) and N,N'-carbonyl diimidazole (13.12 g, 81 mmol) in CH3CN was stirred at room temperature for 1 h. Allyl bromide (53.43 g, 442 mmol) was added and the reaction was heated at reflux for 24 h. The reaction was cooled to room temperature and brine and EtOAc were added. The aqueous solution was extracted with EtOAc and the organic solution was dried (MgSO4), filtered, and concentrated. Flash chromatography provided the title compound in about 85% yield. 1H NMR (400 MHz, CDCl3) δ 7.30-7.09 (m, 4H), 3.38 (t, 2H), 2.76 (t, 2H), 2.15 (t, 2H).
References:
US6288120,2001,B1
22991-03-3
32 suppliers
$45.00/50mg
91085-89-1
16 suppliers
$110.00/100mg
587-04-2
412 suppliers
$7.00/25g
91085-89-1
16 suppliers
$110.00/100mg
103040-43-3
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91085-89-1
16 suppliers
$110.00/100mg
108-37-2
357 suppliers
$6.00/10g
109-64-8
496 suppliers
$10.00/5g
91085-89-1
16 suppliers
$110.00/100mg