1-(4-CHLOROPHENYL)PIPERAZINE HYDROCHLORIDE synthesis

Yield: 90%

Reaction Conditions:

with 2-(2-methoxyethoxy)ethyl alcohol at 150; for 12 h;

Steps:

5.1.5. 1-(2-Methoxyphenyl)piperazine hydrochloride (7c)
General procedure: A mixture of 2-methoxyaniline (369.4 mg, 3 mmol), bis(2-chloroethyl)amine hydrochloride (535.5 mg, 3 mmol) and diethyleneglycol monomethyl ether (0.75 mL) was heated at 150 °C for about 12 h. The reaction mixture was cooled to room temperature and dissolved in methanol (4 mL), followed by the addition of diethyl ether (150 mL). The precipitate formed was recovered byfiltration and washed with diethyl ether to obtain 7c as an HCl salt(510 mg, 74%). The HCl salt was used for the next reaction without further purification.

References:

Paudel, Suresh;Acharya, Srijan;Yoon, Goo;Kim, Kyeong-Man;Cheon, Seung Hoon [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 21,p. 5546 - 5555]